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CCND1 — PRL

Text-mined interactions from Literome

Schuler et al., Biochem Soc Trans 2001 : In order to examine the mechanisms by which prolactin may exert trophic effects on its target tissues during development, we have examined the signalling pathways through which prolactin binding to the long receptor regulates the transcription of cyclin D1
Schroeder et al., Mol Endocrinol 2002 (Adenocarcinoma...) : The expression of cyclin D1 , a critical regulator of the G1/S transition, was significantly increased by PRL and was associated with hyperphosphorylation of retinoblastoma protein at Ser ( 780 )
Brockman et al., Mol Endocrinol 2002 (Breast Neoplasms) : PRL activates the cyclin D1 promoter via the Jak2/Stat pathway ... PRL also increases cyclin D1 levels 2-fold, which can be inhibited by actinomycin D, suggesting that transcriptional increases in cyclin D1 are important
Acosta et al., Mol Endocrinol 2003 : Moreover, we show that both c-Src/PI3K and c-Src/Fak/Erk1/2 pathways are involved in the up-regulation of c-myc and cyclin d1 expression mediated by PRL
Brockman et al., Mol Cell Endocrinol 2005 : This suggests a role for Oct-1 in PRL dependent control of cyclin D1 transcription
Carver et al., Mol Cancer Res 2008 (Breast Neoplasms...) : Insulin-like growth factor (IGF)-II is a required intermediate for prolactin induced up-regulation of cyclin D1 and proliferation in normal murine mammary epithelial cells in vivo and in vitro ... However, we have recently shown that prolactin can rapidly induce cyclin D1 protein expression and subsequent proliferation in the MCF-7 human breast cancer cell line, suggesting that prolactin actions can be independent of IGFs in breast disease ... Moreover, prolactin increased cyclin D1 in the presence of the IGF-I receptor neutralizing antibody alphaIR3
Chan et al., EMBO J 2010 : Depletion of PIKE-A in HC11 epithelial cells diminished PRL induced STAT5 activation and cyclin D1 expression, resulting in profoundly impaired cell proliferation in vitro