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CPOX — CXCL12

Text-mined interactions from Literome

Katoh et al., Am J Pathol 2010 (Neoplasms...) : Notably, COX-2 inhibition attenuated CXCL12/CXCR4 expression as well as expression of several other chemokines
Obermajer et al., Cancer Res 2011 (Ovarian Neoplasms) : Similarly, COX2 inhibition also blocked CXCL12 production in the ovarian cancer environment and its ability to attract MDSCs. Together, our findings elucidate a central role for PGE ( 2 ) in MDSC accumulation triggered by the CXCL12-CXCR4 pathway, providing a powerful rationale to target PGE ( 2 ) signaling in ovarian cancer therapy