◀ Back to STK11

CAB39 — STK11

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: STK11 → Complex of CAB39-STK11-STRADA (increases, CAB39/STK11/STRADA Activity)
  
  Evidence: When complexed with STRAD and MO25, LKB1 shows constitutive activation in vitro (that is, for LKB1 to be catalytically active, it does not require phosphorylation by an upstream kinase).
• OpenBEL Selventa BEL large corpus: STK11 → Complex of CAB39-STK11-STRADA (directlyIncreases, CAB39/STK11/STRADA Activity)
  Lizcano et al., EMBO J 2004*
  Evidence: We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and activates AMP-activated protein kinase (AMPK).
• NCI Pathway Database LKB1 signaling events: STRADA-STRADB (STRADA/STRADB) → LKB1/MO25/STRADA-STRADB complex (STK11-CAB39-STRADA_STRADB) (modification, collaborate)
  Baas et al., EMBO J 2003, Hawley et al., Journal of biology 2003, Boudeau et al., EMBO J 2003, Brajenovic et al., J Biol Chem 2004, Zeqiraj et al., PLoS Biol 2009*
  Evidence: assay, physical interaction
• NCI Pathway Database LKB1 signaling events: MO25 (CAB39) → LKB1/MO25/STRADA-STRADB complex (STK11-CAB39-STRADA_STRADB) (modification, collaborate)
  Baas et al., EMBO J 2003, Hawley et al., Journal of biology 2003, Boudeau et al., EMBO J 2003, Brajenovic et al., J Biol Chem 2004, Zeqiraj et al., PLoS Biol 2009*
  Evidence: assay, physical interaction
• NCI Pathway Database LKB1 signaling events: MO25 (CAB39) → LKB1 (STK11) (modification, collaborate) Baas et al., EMBO J 2003, Hawley et al., Journal of biology 2003, Boudeau et al., EMBO J 2003, Brajenovic et al., J Biol Chem 2004, Zeqiraj et al., PLoS Biol 2009*
  Evidence: assay, physical interaction
• NCI Pathway Database LKB1 signaling events: LKB1/MO25/STRADA-STRADB complex (STK11-CAB39-STRADA_STRADB) → LKB1 (STK11) (modification, collaborate) Baas et al., EMBO J 2003, Hawley et al., Journal of biology 2003, Boudeau et al., EMBO J 2003, Brajenovic et al., J Biol Chem 2004, Zeqiraj et al., PLoS Biol 2009*
  Evidence: assay, physical interaction
• NCI Pathway Database LKB1 signaling events: AMPKK1-AMPKK2 () → LKB1/MO25/STRADA-STRADB complex (STK11-CAB39-STRADA_STRADB) (modification, collaborate)
  Hawley et al., Journal of biology 2003, Woods et al., Curr Biol 2003, Lizcano et al., EMBO J 2004*, Shaw et al., Proc Natl Acad Sci U S A 2004, Jaleel et al., Biochem J 2006*
  Evidence: mutant phenotype, assay
• Reactome Reaction: CAB39 → STK11 (reaction) Baas et al., EMBO J 2003, Boudeau et al., EMBO J 2003
• Reactome Reaction: CAB39 → STK11 (direct_complex) Baas et al., EMBO J 2003, Boudeau et al., EMBO J 2003
• WikiPathways AMP-activated Protein Kinase (AMPK) Signaling: Complex of STRADA-STRADB-STK11-CAB39 → Complex of PRKAG3-PRKAA1-PRKAG2-PRKAG1-PRKAB2-PRKAB1-PRKAA2 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: Complex of 15 proteins Brajenovic et al., J Biol Chem 2004
• IRef Bind_translation Interaction: CAB39 — STK11 (affinity chromatography technology) Brajenovic et al., J Biol Chem 2004
• IRef Bind_translation Interaction: CAB39 — STK11 (coimmunoprecipitation) Brajenovic et al., J Biol Chem 2004
• IRef Biogrid Interaction: CAB39 — STK11 (physical association, affinity chromatography technology) Boudeau et al., J Cell Sci 2004*
• IRef Biogrid Interaction: CAB39 — STK11 (physical association, affinity chromatography technology) Behrends et al., Nature 2010
• IRef Biogrid Interaction: CAB39 — STK11 (physical association, affinity chromatography technology) Brajenovic et al., J Biol Chem 2004
• MIPS CORUM LKB1-STRAD-MO25 complex: LKB1-STRAD-MO25 complex complex (CAB39-STK11-STRADA) Zeqiraj et al., Science 2009*
• IRef Dip Interaction: CAB39 — STK11 (physical association, pull down) Zeqiraj et al., PLoS Biol 2009*
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Boudeau et al., EMBO J 2003, Lizcano et al., EMBO J 2004*, Baas et al., Trends Cell Biol 2004*, Boudeau et al., J Cell Sci 2004*
• IRef Hprd Interaction: CAB39 — STK11 (in vivo) Brajenovic et al., J Biol Chem 2004
• IRef Intact Interaction: Complex of FKBP5-STRADA-CAB39-STK11-STK11-CAB39L-STRADB-CDC37 (physical association, anti tag coimmunoprecipitation) Behrends et al., Nature 2010
• IRef Intact Interaction: CAB39 — STK11 (physical association, anti tag coimmunoprecipitation) Brajenovic et al., J Biol Chem 2004
• IRef Intact Interaction: CAB39 — STK11 (physical association, affinity chromatography technology) Jaleel et al., FEBS Lett 2005*
• IRef Intact Interaction: Complex of 15 proteins (association, anti tag coimmunoprecipitation) Brajenovic et al., J Biol Chem 2004

Text-mined interactions from Literome

Ellingson et al., Am J Physiol Endocrinol Metab 2007 : These results have identified 3-PG as an AMPK-specific regulator of AMPK phosphorylation and activation by LKB1-STRAD-MO25
Zeqiraj et al., PLoS Biol 2009 (Abnormalities, Multiple...) : Mutagenesis studies reveal that association of STRADalpha with either ATP or MO25alpha is essential for LKB1 activation
Zeqiraj et al., Science 2009 : LKB1 activity is regulated by the pseudokinase STRADalpha and the scaffolding protein MO25alpha through an unknown, phosphorylation independent, mechanism