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MAPK8 — MAPKAPK2
Text-mined interactions from Literome
Bartlett et al., J Physiol 1999
:
Induction of
MAPKAP kinase-2 activity was
prevented by the p38
MAPK inhibitor SB 203580 ( 10 microm, 5-30 min )
Martel-Pelletier et al., Arthritis Rheum 1999
(Osteoarthritis) :
Mitogen activated protein kinase and nuclear factor kappaB together regulate interleukin-17 induced nitric oxide production in human osteoarthritic chondrocytes : possible role of transactivating factor
mitogen activated protein kinase activated proten kinase (
MAPKAPK )
Aicher et al., J Immunol 1999
:
The p38
MAPK-specific inhibitor, SB203580,
blocked CD40 induced
MAPKAPK-2 activation, but did not affect activation of c-Jun N-terminal kinase
Ishizuka et al., J Immunol 2001
:
Both p38
MAPK and MAPK activated protein kinase (MAPKAPK)2 were activated following Fc ( epsilon ) RI aggregation, and activation of
MAPKAPK2 was almost completely
inhibited by 10 microM SB203580
Matsuda et al., Cancer Res 2002
(MAP Kinase Signaling System...) :
In ASPC-1, PANC-1, and T3M4 cells, PD98059 and U0126 inhibited
MAPK kinase activation but not EGF stimulated mitogenesis, whereas SB203580
inhibited EGF stimulated mitogenesis, p38 MAPK activation, and
MAPK activated protein kinase 2 activation, without attenuating the mitogenic effect of insulin-like growth factor 1
Fegley et al., J Surg Res 2003
:
S-1-P stimulated activation of p38 (
MAPK ) that peaked at 10 min, as well as
activation of
MAPKAP kinase-2
Coxon et al., Cell Signal 2003
(MAP Kinase Signaling System) :
MAPK activated protein kinase-2 (MK2) is
activated by p38
MAPK in human neutrophils
Hu et al., J Biol Chem 2006
(MAP Kinase Signaling System) :
MAPKAPK-2 , Akt2, and ezrin phosphorylation were all
attenuated by p38
MAPK inhibition but were unaffected by dominant negative ezrin expression ... siRNA mediated
MAPKAPK-2 knockdown
inhibited phosphorylation of Akt2 and ezrin but not p38
MAPK
Su et al., Biochim Biophys Acta 2008
(MAP Kinase Signaling System) :
TNF stimulation induced p38
MAPK dependent phosphorylation of
MK2 and HSP27
Duraisamy et al., Expert Opin Ther Targets 2008
(Inflammation) :
Mitogen activated protein kinase (
MAPK) activated protein kinase 2 (MK2 ) is
activated upon stress by p38
MAPK
Dingar et al., Cell Signal 2010
(Cardiomegaly...) :
Whereas
MK2 and MK3 are
activated by p38
MAPK , MK5 has also been shown to be activated by ERK3 and ERK4
Shiryaev et al., Journal of molecular signaling 2011
:
Stimulation of the
p38MAPK , but not the PKA pathway,
caused activation of
MK2
Anur et al., Blood 2012
(Disease Models, Animal...) :
Low doses ( 50nM ) of both agents inhibited p38
MAPK dependent activation of
MAPKAPK2 (MK2) and suppressed MK2 dependent TNFa production without substantially influencing TNFa gene transcription
Xu et al., PloS one 2012
(Breast Neoplasms) :
PIC induced activation of p38 MAPK and
MK2 was attenuated by the PKR inhibitor and the PKR siRNA, but a selective p38
MAPK inhibitor ( SB203580 ) or other MAPK inhibitors did not
affect PKR activity, indicating that PKR is upstream of p38 MAPK/MK2
Huot et al., Eur J Biochem 1995
:
In all cases, the induced kinase activity was entirely associated with two polypeptides of 45 kDa and 54 kDa, identified as
mitogen-activated-protein kinase activated protein (
MAPKAP) kinase-2 based on its reactivation in vitro by 42/44-kDa MAP kinases, its antigenic properties and its substrate specificity
Groblewski et al., Gastroenterology 1997
:
Cholecystokinin stimulated
mitogen activated protein kinase activated protein (
MAPKAP) kinase 2 activity was measured after immunoprecipitation of the kinase
Komatsu et al., Arch Biochem Biophys 1997
:
The protein kinase activity of
GST-MAPKAPK-4 was
activated by
MAPK and this enabled the kinase to phosphorylate both glycogen synthase N-terminal peptide and the regulatory light chain of myosin II in vitro
Hodge et al., J Biol Chem 1998
:
GH slightly increased p38 mediated
mitogen activated protein kinase activated protein (
MAPKAP) kinase-2 activity, but the p38 inhibitor SB203580 did not attenuate GH-promoted Elk-1 phosphorylation
Marshall et al., J Immunol 1998
:
IL-4 induced a late ( > 4-h ) increase in p38
MAPK activity and corresponding
activation of its substrate
MAPKAPK-2