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AGTR2 — IL6
Text-mined interactions from Literome
Hochart et al., Br J Haematol 2006
(Bacterial Infections...) :
Proinflammatory cytokines tumour necrosis factor (TNF)-alpha, interleukin (IL)-8, IL-6 and IL-1beta release were subsequently measured by enzyme linked immunosorbent assay at 6 h, and nuclear translocation of the proinflammatory NF-kappaB was assessed
at 2 h. Treatment with pharmacological doses of LMWH and UFH significantly
attenuated LPS induced production of TNF-alpha, IL-8,
IL-6 and IL-1beta as well as NF-kappaB translocation
Chen et al., World J Gastroenterol 2009
(Pancreatitis) :
After treatment with 5-FU, TNF-alpha, IL-1, and
IL-6 in serum of rats of Group C were
inhibited at 2 and 6 h after operation ( P < 0.05 ), and IL-10, TGF-beta were inhibited at 24 h compared to Group B ( P < 0.05 )
Matavelli et al., Hypertension 2011
(Body Weight...) :
We hypothesized that direct
AT2R stimulation
reduces renal production of the inflammatory cytokines tumor necrosis factor-a (TNF-a),
interleukin-6 (IL-6) , and transforming growth factor-ß1 ( TGF-ß1 ) and enhances the production of nitric oxide ( NO ) and cyclic guanosine 3',5'-monophosphate ( cGMP ) in the clipped kidney of 2-kidney, 1-clip ( 2K1C ) hypertension rat model
Martino et al., World journal of gastrointestinal surgery 2012
:
TNF-a and
IL-6 serum levels
increased at 2 and 6 h after hepatectomy
Neta et al., Lymphokine Res 1988
(Acute-Phase Reaction) :
IL 1 in doses above 10 ng/mouse induced within 2 to 6 hrs a dose dependent increase in CSF in circulation, but
IL 6 did not
induce detectable levels of CSF
at 2 , 6 and 20 hrs after administration
Wood et al., Exp Dermatol 1997
:
Following tape stripping, only the mRNA levels for TNF-alpha, IL-1 alpha, IL-1 beta and
IL-6 increased
at 2.5 and 7 h, and returned toward normal levels by 18 h
Gao et al., Planta Med 1997
:
T2a-T2d induced human monocytes to produce interleukin-1 (IL-1),
interleukin-6 (IL-6), and tumor necrosis factor (TNF) in vitro
Tashiro et al., Nutrition 1998
(Burns...) :
In the group of patients fed by total parenteral nutrition with soybean oil emulsion, the serum
IL-6 significantly
increased at 2 and 6 h after operation ( P < 0.05 )
Wang et al., Brain Res 1999
:
Both responses reached a peak at around 2-3 h. Mouse IL-1beta administration ( 100 ng, i.p. ) induced large increases in plasma corticosterone and a substantial, but short lived
increase in plasma
IL-6 with a peak
at 2 h. Pretreatment of mice intraperitoneally with a monoclonal antibody to mouse IL-6 significantly attenuated the plasma ACTH and corticosterone responses to LPS at 3 h, but not at 1 h. Anti-IL-6 treatment also attenuated the LPS induced increases of tryptophan and the serotonin catabolite, 5-hydroxyindoleacetic acid ( 5-HIAA ), but not that of the norepinephrine catabolite, 3-methoxy,4-hydroxyphenylethyleneglycol ( MHPG )