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CCL2 — HGF
Text-mined interactions from Literome
Wang et al., Miner Electrolyte Metab 1999
(Diabetic Nephropathies...) :
TGF-beta and
HGF cause increased expression and basolateral secretion of
MCP-1 in proximal tubular and collecting duct cells
Amano et al., J Immunol 2004
(Acute Disease...) :
Furthermore,
MCP-1/CCL2 enhanced the ingestion of apoptotic neutrophils and
HGF production by a mouse macrophage cell line, RAW 267.4, in a dose dependent manner
Dankbar et al., J Orthop Res 2007
(Osteoarthritis) :
In a series of subsequent in vitro studies,
HGF remarkable
induced MCP-1 secretion by FLS in a dose dependent manner
Kadoyama et al., Neurosci Res 2007
(Amyotrophic Lateral Sclerosis...) :
HGF overexpression
attenuated monocyte chemoattractant protein-1 ( MCP-1 ) induction, predominantly in astrocytes ; suppressed activation of caspase-1, -3 and -9 ; and, increased X chromosome linked inhibition of apoptosis protein ( XIAP ) in the motoneurons of G93A mice
Kaga et al., Vascul Pharmacol 2012
(Inflammation) :
In addition, bFGF, but not
HGF or VEGF, significantly
activated an essential transcription factor for inflammation, NF?B, and gene expression of its downstream inflammation related cytokines ( IL-8 and
MCP-1 ) in VSMCs, accompanied by an increase in the vascular permeability in the rat paper disc model
Müller et al., J Neuroimmunol 2012
(Astrocytoma...) :
We conclude that the expression of HGF within the CNS is reflective of disease activity in MS and this may be due to decreased
induction of
HGF by
CCL2