Gene interactions and pathways from curated databases and text-mining

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CCL2 — HGF

Text-mined interactions from Literome

Wang et al., Miner Electrolyte Metab 1999 (Diabetic Nephropathies...) : TGF-beta and HGF cause increased expression and basolateral secretion of MCP-1 in proximal tubular and collecting duct cells
Amano et al., J Immunol 2004 (Acute Disease...) : Furthermore, MCP-1/CCL2 enhanced the ingestion of apoptotic neutrophils and HGF production by a mouse macrophage cell line, RAW 267.4, in a dose dependent manner
Dankbar et al., J Orthop Res 2007 (Osteoarthritis) : In a series of subsequent in vitro studies, HGF remarkable induced MCP-1 secretion by FLS in a dose dependent manner
Kadoyama et al., Neurosci Res 2007 (Amyotrophic Lateral Sclerosis...) : HGF overexpression attenuated monocyte chemoattractant protein-1 ( MCP-1 ) induction, predominantly in astrocytes ; suppressed activation of caspase-1, -3 and -9 ; and, increased X chromosome linked inhibition of apoptosis protein ( XIAP ) in the motoneurons of G93A mice
Kaga et al., Vascul Pharmacol 2012 (Inflammation) : In addition, bFGF, but not HGF or VEGF, significantly activated an essential transcription factor for inflammation, NF?B, and gene expression of its downstream inflammation related cytokines ( IL-8 and MCP-1 ) in VSMCs, accompanied by an increase in the vascular permeability in the rat paper disc model
Müller et al., J Neuroimmunol 2012 (Astrocytoma...) : We conclude that the expression of HGF within the CNS is reflective of disease activity in MS and this may be due to decreased induction of HGF by CCL2