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EPHB2 — JAK2

Text-mined interactions from Literome

Takaoka et al., EMBO J 1999 : Thus, the two types of IFN may utilize distinct Jak mediated Erk2 , and possibly other MAPK activation pathways for their antiviral action
Dijkers et al., Oncogene 1999 : Overexpression of JAK2 was sufficient to activate both protein kinase B (PKB) and extracellular regulated kinase-1 (ERK1)
Niculescu et al., Immunopharmacology 1999 : Therefore, JAK1 activity may be involved in activation of Raf-1 and ERK1 via G proteins activated by C5b-9
Kim et al., Mol Cell Biol 2001 : These results indicate that the interaction between TFII-I and ERK , which is essential for its activity, can be regulated by JAK2 through phosphorylation of TFII-I at tyrosine 248
Ho et al., Blood 2002 : Our data reveal the requirement of ERK activation by TEL-JAK2 ( 5-19 ) in Ba/F3 cells and suggest that TEL-JAK2 leukemogenic potential may be mediated in part through ERK1/2
Zhu et al., J Leukoc Biol 2002 : ERK1/2 phosphorylation and eosinophil adhesion were blocked by inhibition of the src-family tyrosine kinase, Janus tyrosine kinase (JAK)2 , or phosphoinositide-3 kinase (PI3K)
Pai et al., Biochem Biophys Res Commun 2005 (Stomach Neoplasms) : While JAK inhibition with AG490 significantly reduced leptin induced ERK2 , STAT3 phosphorylation, and cell proliferation, SHP2 inhibition only partially reduced cancer cell proliferation
Chen et al., FEBS Lett 2005 : Inhibition of TK or JAK2 activities blocked magnolol induced phosphorylation of MEK and ERK , again supporting the upstream role of JAK2
Wang et al., Blood 2006 (MAP Kinase Signaling System...) : TCCM treatment activated p38 mitogen activated protein kinase ( MAPK ) and Janus kinase ( JNK ) but inhibited extracellular regulated kinase (ERK)
Sharma et al., Endocr Relat Cancer 2006 (Endometrial Neoplasms...) : Moreover, leptin induced phosphorylation of ERK2 and AKT was dependent on JAK/STAT activation
Ogunwobi et al., Endocrinology 2006 (Adenocarcinoma...) : The activation of ERK and Akt but not p38 MAPK was JAK2 dependent
Arany et al., Kidney Int 2006 : Inhibition of JAK2 or STAT3 lead to increased ERK activation and survival of TKPTS cells during severe oxidative stress
Cao et al., J Hepatol 2007 (Liver Cirrhosis...) : The repression was mediated by JAK/STAT pathway in synergism with JAK mediated H2O2 dependent ERK1/2 and p38 pathways ... Leptin represses MMP-1 gene expression via the synergistic actions of the JAK/STAT pathway and JAK mediated H2O2 dependent ERK1/2 and p38 pathways
El Mabrouk et al., Biochim Biophys Acta 2007 : Furthermore, JAK3 inhibition time-dependently down-regulated Akt but not ERK1/2 phosphorylation suggesting that Akt is a downstream target of JAK3
Kanda et al., Endocrinology 2007 (MAP Kinase Signaling System...) : Prolactin induced phosphorylation of JAK2 and ERK , whereas IFN-gamma induced phosphorylation of JAK1, JAK2 , and p38 MAPK
Saxena et al., Cancer Res 2007 (Carcinoma, Hepatocellular...) : Leptin induced phosphorylation of ERK and AKT was dependent on Janus activated kinase ( JAK ) /STAT activation
Luo et al., Eur J Neurosci 2007 (Optic Nerve Injuries) : In this study we showed that : ( i ) the RGC protection was pathway inhibition dependent ; ( ii ) inhibition of PI3K/akt and JAK/STAT, but not MEK/ERK , activated macrophages in the eye, ( iii ) macrophage removal from the eye using clodronate liposomes significantly impeded PI3K/akt and JAK/STAT inhibition induced RGC survival and axon regeneration whereas it only slightly affected MEK/ERK inhibition dependent protection ; ( iv ) in the absence of recruited macrophages in the eye, inhibition of PI3K/akt or JAK/STAT did not influence RGC survival ; and ( v ) strong PI3K/akt, JAK/STAT and MEK/ERK pathway activities were located in RGCs but not macrophages after ON injury
Jin et al., Mol Endocrinol 2008 (Liver Neoplasms, Experimental...) : JAK2 , but not Src family kinases, is required for STAT, ERK , and Akt signaling in response to growth hormone in preadipocytes and hepatoma cells
Trimarchi et al., J Neurochem 2009 : These results indicate that CNTF evoked stimulation of T-type Ca ( 2+ ) channel expression in chicken nodose neurons requires JAK dependent ERK signaling
Wang et al., Mol Endocrinol 2009 : We previously reported that IRS-1 and Janus kinase 2 associate independently of tyrosine phosphorylation via IRS-1 's N terminus and that IRS-1 reconstitution greatly enhances GH-induced ERK , but not STAT5, activation
Qi et al., J Cell Physiol 2009 : IFN-gamma induced phosphorylation of JAK1 and JAK2 , whereas TNF-alpha induced phosphorylation of ERK1/2
Fukumoto et al., Cell Signal 2009 (Leukemia, Erythroblastic, Acute) : The co-immunoprecipitation experiments using the Jak inhibitor AG490 or siRNA duplexes targeting Jak2 and in vitro binding experiments demonstrated that Jak2 regulated Gab1 mediated Erk activation through tyrosine phosphorylation of Gab1
Akada et al., Blood 2010 (Disease Models, Animal...) : Biochemical analyses revealed Jak2V617F gene dosage dependent activation of Stat5, Akt, and Erk signaling pathways
Kittilson et al., Frontiers in endocrinology 2011 : JAK2 inhibition completely blocked activation of ERK , Akt, and STAT5, suggesting that all of these pathways link to GHR1 and GHR2 via JAK2
Winston et al., J Biol Chem 1995 : We have used a transient transfection system in 293 cells to evaluate the requirement for JAK2 in the activation of ERK2/MAPK by GH ... We found that JAK2 is required for GH-simulated activation of ERK2/MAPK ... Employing the transient expression of dominant negative forms of H-Ras and Raf-1, we determined that the GHR/JAK2 mediated activation of ERK2/MAPK is dependent on both Ras and Raf
Sengupta et al., Proc Natl Acad Sci U S A 1998 : These results demonstrate an ERK mediated mechanism for inhibiting IL-6 induced Jak-STAT signaling that is rapid and inducible, and thus differs from previously described mechanisms for downmodulation of the Jak-STAT pathway