Gene interactions and pathways from curated databases and text-mining

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EGF — RPS6

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: RPS6 → EGF (increases) Olsen et al., Cell 2006*
    Evidence: We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database

Text-mined interactions from Literome

Galbaugh et al., BMC cell biology 2006 : The activation of p70S6K by insulin or EGF resulted in the phosphorylation of ribosomal protein S6 (RPS6) , elongation initiation factor 4E ( elF4E ) and 4E binding protein1 (4E-BP1)
Perisic et al., FEBS Lett 1985 : Protease activated kinase II as the mediator of epidermal growth factor stimulated phosphorylation of ribosomal protein S6