Gene interactions and pathways from curated databases and text-mining

◀ Back to EGF

CTCF — EGF

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: CTCF → EGF (decreases) Olsen et al., Cell 2006*
    Evidence: We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database

Text-mined interactions from Literome

Li et al., J Biol Chem 2005 (MAP Kinase Signaling System) : EGF induced CCCTC binding factor (CTCF) activation subsequently inhibited Pax6 expression by interacting with a CTCF-specific region upstream of the pax6 P0 promoter ... Suppression of EGF induced Erk activation by specific inhibitor or by the dominant expression of a silent Erk mutant effectively abolished the effects of EGF stimulation on regulations of CTCF and pax6
Wu et al., Invest Ophthalmol Vis Sci 2006 : In addition, ultraviolet ( UV ) irradiation and epidermal growth factor (EGF) induced suppression and activation of CTCF expression, respectively
Lu et al., J Biol Chem 2010 : In this study, we show that epidermal growth factor (EGF) induced increase and UV stress induced decrease in CTCF activities mediate human corneal epithelial cell proliferation and apoptosis, respectively ... CTCF is regulated by activation of different NF-kappaB subtypes via stimulation by EGF and UV stress
Wang et al., PloS one 2011 : Previous studies found in corneal epithelial cells that CTCF is regulated by epidermal growth factor (EGF) through activation of NF-?B p65/p50
Wang et al., J Biol Chem 2012 : Previous studies found that CTCF is positively and negatively regulated at the transcriptional level by epidermal growth factor (EGF) and ultraviolet ( UV ) stimulation, respectively
Wang et al., J Biol Chem 2013 : Thus, a direct regulatory relationship between EGF induced NF?B p50 and CTCF activation affecting corneal epithelial wound healing has been established, indicating that CTCF is, indeed, a NF?B p50 targeted and effective gene product in the core transcriptional network downstream from the growth factor induced NF?B signaling pathway