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GAB1 — RELA

Text-mined interactions from Literome

Che et al., Circ Res 2002 : Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells : role of Gab1 and MEKK3 in TNF-alpha induced c-Jun and NF-kappaB activation and adhesion molecule expression ... Because Gab1 is involved in both c-Jun and NF-kappaB activation by TNF-alpha, we focused on Gab1 dependent signaling ... Gab1 associated with MEKK3, and a catalytically inactive form of MEKK3 inhibited TNF-alpha induced c-Jun and NF-kappaB transcriptional activation, suggesting a critical role for Gab1 and MEKK3 in TNF-alpha signaling
Lerner-Marmarosh et al., Arterioscler Thromb Vasc Biol 2003 (Inflammation) : Because MEKK3 and Gab1 are critical for TNF-alpha induced c-Jun and NF-kappaB activation, we determined the role of SHP-2 phosphatase activity in MEKK3 signaling ... A catalytically inactive form of SHP-2 increased MEKK3/Gab1 interaction and inhibited MEKK3 ( but not MEKK1 ) -mediated c-Jun and NF-kappaB activation
Kapoor et al., Mol Cell Biol 2004 (Glioblastoma) : Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells ... On the other hand, ectopic overexpression of either a Gab1 mutant incapable of binding to SHP-2 ( Y627F ) or a phosphatase-inactive SHP-2 mutant ( C459S ) caused a significant increase in NF-kappaB activity