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EIF2S1 — RELA

Text-mined interactions from Literome

Gil et al., Oncogene 2000 : Apoptosis induction by PKR involves phosphorylation of the translational factor eIF-2alpha and activation of the transcriptional factor NF-kappaB , but caspase pathways activated by PKR are not known
Gil et al., Apoptosis 2000 : The mechanism of apoptosis induction by PKR involves phosphorylation of eIF-2 alpha and activation of NF-kappa B
Gil et al., Oncogene 2001 : Moreover, the mutant PKR ( K296R ) acts as a dominant negative of PKR induced eIF-2alpha phosphorylation and NF-kappaB activation
Jiang et al., Mol Cell Biol 2003 : During impaired protein folding and assembly in the endoplasmic reticulum ( ER ), phosphorylation of eIF2alpha by PEK ( Perk or EIF2AK3 ) is essential for induction of NF-kappaB transcriptional activity
Deng et al., Mol Cell Biol 2004 : It has been noted that conditions associated with eIF2alpha phosphorylation, notably accumulation of unfolded proteins in the endoplasmic reticulum ( ER ), or ER stress, are also associated with activation of nuclear factor kappa B (NF-kappaB) and that eIF2alpha phosphorylation is required for NF-kappaB activation by ER stress ... We have used a pharmacologically activable version of pancreatic ER kinase ( PERK, an ER stress-responsive eIF2alpha kinase ) to uncouple eIF2alpha phosphorylation from stress and found that phosphorylation of eIF2alpha is both necessary and sufficient to activate both NF-kappaB DNA binding and an NF-kappaB reporter gene
László et al., Mol Cell Biochem 2009 : We illustrate a newly developed mechanism of eIF2alpha kinase mediated IkappaB depletion and subsequent NF-kappaB activation
Offermann et al., Eur J Biochem 1995 : Incubation of HUVE cells with the synthetic dsRNA, poly ( I ) .poly ( C ), activates PKR with increased autophosphorylation, increased phosphorylation of the translation factor eIF2 alpha , and increased activation of the transcription factor NF-kappa B