◀ Back to IRAK2
IRAK1 — IRAK2
Pathways - manually collected, often from reviews:
-
BioCarta signal transduction through il1r:
IRAKs (IRAK3/IRAK1/IRAK2)
→
IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
IRAKs (IRAK3/IRAK1/IRAK2)
→
IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
(modification, collaborate)
-
KEGG Apoptosis:
IL1R1/IL1RAP
→
Complex of IRAK1-IRAK2-IRAK3-IRAK4-MYD88
(protein-protein, activation)
-
KEGG Neurotrophin signaling pathway:
Complex of IRAK1-IRAK2-IRAK3-IRAK4-TRAF6
→
IKBKB
(protein-protein, activation)
-
NCI Pathway Database Endogenous TLR signaling:
IRAK2 (IRAK2)
→
IRAK (IRAK1)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK2 (IRAK2)
→
HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR4-LY96-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-HMGB1-MYD88-TIRAP)
→
HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR4-LY96-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK4 (IRAK4)
→
HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR4-LY96-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK (IRAK1)
→
HMGB1/TLR4/MD2 (dimer)/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR4-LY96-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK2 (IRAK2)
→
IRAK (IRAK1)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK2 (IRAK2)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK4 (IRAK4)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK (IRAK1)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
WikiPathways Regulation of toll-like receptor signaling pathway:
IRAK2
→
IRAK1
(unknown)
-
WikiPathways Structural Pathway of Interleukin 1 (IL-1):
IRAK1
→
IRAK2
(unknown)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
IRAK2
—
IRAK1
(coimmunoprecipitation)
Wesche et al., J Biol Chem 1999
-
IRef Bind_translation Interaction:
IRAK2
—
IRAK1
(experimental interaction detection)
Wesche et al., J Biol Chem 1999
-
IRef Biogrid Interaction:
IRAK2
—
IRAK1
(direct interaction, fluorescent resonance energy transfer)
Ross et al., J Biol Chem 2002
-
IRef Biogrid Interaction:
IRAK2
—
IRAK1
(physical association, affinity chromatography technology)
Li et al., Immunity 2011
-
MIPS CORUM IRAK1-IRAK2 complex:
IRAK1-IRAK2 complex complex (IRAK1-IRAK2)
Wesche et al., J Biol Chem 1999
-
IRef Corum Interaction:
IRAK2
—
IRAK1
(association, coimmunoprecipitation)
Wesche et al., J Biol Chem 1999
-
IRef Hprd Interaction:
IRAK1
—
IRAK2
(in vivo)
Wesche et al., J Biol Chem 1999
-
IRef Innatedb Interaction:
IRAK2
—
IRAK1
(unknown, -)
Wesche et al., J Biol Chem 1999
-
IRef Innatedb Interaction:
IRAK2
—
IRAK1
(unknown, -)
Rao et al., Mol Cell Biol 2005
-
IRef Intact Interaction:
IRAK2
—
IRAK1
(physical association, anti tag coimmunoprecipitation)
Wesche et al., J Biol Chem 1999
-
IRef Intact Interaction:
Complex of 11 proteins
(association, anti tag coimmunoprecipitation)
Li et al., Immunity 2011
-
IRef Intact Interaction:
Complex of 18 proteins
(association, anti tag coimmunoprecipitation)
Li et al., Immunity 2011
-
IRef Intact Interaction:
Complex of 19 proteins
(association, anti tag coimmunoprecipitation)
Li et al., Immunity 2011
-
IRef Intact Interaction:
Complex of IRAK1-IRAK3-IRAK2-IRAK2-IRAK1-IRAK3
(association, anti tag coimmunoprecipitation)
Li et al., Immunity 2011
-
IRef Intact Interaction:
Complex of 20 proteins
(association, anti tag coimmunoprecipitation)
Li et al., Immunity 2011
-
IRef Intact Interaction:
Complex of IRAK4-IRAK2-IRAK1-IRAK2-IRAK4-IRAK1
(association, anti tag coimmunoprecipitation)
Li et al., Immunity 2011
Text-mined interactions from Literome
Li et al., Proc Natl Acad Sci U S A 2002
(MAP Kinase Signaling System) :
In addition,
IRAK-4 is able to phosphorylate IRAK-1, and overexpression of dominant negative IRAK-4 is
blocking the IL-1 induced activation and modification of
IRAK-1 , suggesting a role of IRAK-4 as a central element in the early signal transduction of Toll/IL-1 receptors, upstream of IRAK-1
Oak et al., J Immunol 2006
(Inflammation...) :
IRAK-monocyte , an
inhibitor of
IRAK-1 , was induced in TLR4, but it was reduced in TLR2- plus TLR4 stimulated monocytes by alcohol
Bennett et al., J Virol 2012
(Picornaviridae Infections) :
Pellino-1 actions were likely to be independent of
interleukin-1 receptor associated kinase-1 (
IRAK-1 )
regulation , since Pellino-1 knockdown in primary epithelial cells did not alter responses to IL-1 but did inhibit responses to poly ( I·C ), a Toll-like receptor 3 (TLR3) activator that does not signal via IRAK-1 to engender a response