Gene interactions and pathways from curated databases and text-mining

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IRAK1 — IRAK2

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Li et al., Proc Natl Acad Sci U S A 2002 (MAP Kinase Signaling System) : In addition, IRAK-4 is able to phosphorylate IRAK-1, and overexpression of dominant negative IRAK-4 is blocking the IL-1 induced activation and modification of IRAK-1 , suggesting a role of IRAK-4 as a central element in the early signal transduction of Toll/IL-1 receptors, upstream of IRAK-1
Oak et al., J Immunol 2006 (Inflammation...) : IRAK-monocyte , an inhibitor of IRAK-1 , was induced in TLR4, but it was reduced in TLR2- plus TLR4 stimulated monocytes by alcohol
Bennett et al., J Virol 2012 (Picornaviridae Infections) : Pellino-1 actions were likely to be independent of interleukin-1 receptor associated kinase-1 ( IRAK-1 ) regulation , since Pellino-1 knockdown in primary epithelial cells did not alter responses to IL-1 but did inhibit responses to poly ( I·C ), a Toll-like receptor 3 (TLR3) activator that does not signal via IRAK-1 to engender a response