Gene interactions and pathways from curated databases and text-mining

◀ Back to RELA

PGF — RELA

Pathways - manually collected, often from reviews:

  • KEGG Pancreatic cancer: NFKB1/RELA → FIGF/PGF/VEGFA/VEGFB/VEGFC (gene expression, expression)

Text-mined interactions from Literome

Mandal et al., J Biol Chem 2005 (Inflammation) : Most importantly, uteroglobin inhibits FP-mediated NF-kappaB activation and cyclooxygenase-2 gene expression by binding and most likely by sequestering PGF2alpha into its central hydrophobic cavity, thereby preventing FP-PGF2alpha interaction and suppressing the production of inflammatory lipid mediators
Taniguchi et al., Reproduction 2010 : PGF ( 2a ) increased NFKB p65 protein expression in the nucleus of luteal cells 30 min after PGF ( 2a ) injection, and electrophoretic mobility shift assay revealed that PGF ( 2a ) increased binding activities of NFKB to the NFKB consensus sequence of the Ptgs2 gene promoter ... Simultaneous administration of both superoxide dismutase and catalase to scavenge reactive oxygen species ( ROS ) inhibited the increases of nuclear NFKB p65 protein expression, lipid peroxide levels, and Ptgs2 mRNA expression induced by PGF ( 2a )