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PI3 — TGFB1

Text-mined interactions from Literome

Chen et al., J Biol Chem 2007 : IKK activation induced by iron is abrogated by overexpression of a dominant negative mutant ( DN ) for transforming growth factor beta activated kinase-1 ( TAK1 ), NF-kappaB inducing kinase, or phosphatidylinositol 3-kinase (PI3K) and by treatment with the mitogen activated protein kinase ( MAPK ) kinase-1 ( MEK1 ) inhibitor
Otsuka et al., FEBS Lett 2007 : We explored the involvement of phosphatidylinositol 3-kinase (PI3K) and ERK pathways in the production of TGF-beta1 by macrophages treated with liposomes composed of phosphatidylserine ( PS-liposomes )
Kang et al., J Exp Med 2007 (Pulmonary Fibrosis) : TGF-beta(1) and bleomycin also activated phosphatidylinositol 3-kinase (PI3K) and protein kinase B (PKB)/AKT via SEMA 7A-dependent mechanisms, and PKB/AKT inhibition diminished TGF-beta(1) induced fibrosis
Wang et al., Mol Cell Biol 2008 (Breast Neoplasms) : In HER2 overexpressing mammary epithelial cells, transforming growth factor beta ( TGF-beta ) activated phosphatidylinositol-3 kinase (PI3K)/Akt and enhanced survival and migration
Mohamed et al., Am J Physiol Lung Cell Mol Physiol 2010 : Interestingly, selective inhibitors of PTK, PI3K , or MEK1/2 attenuated TGF-beta1 expression through blocking ERK1/2 phosphorylation and TGF-beta1 promoter activity in response to stretch
Krymskaya et al., Am J Physiol 1997 : To date, no study has examined the effects of TGF-beta 1 on PI 3-kinase activity ... Although TGF-beta 1 alone did not alter PI 3-kinase activation, TGF-beta 1 markedly enhanced EGF induced PI 3-kinase activity, with a 16.6 +/- 1.9-fold increase over control cells treated with diluent alone ... TGF-beta 1 , however, enhanced PI 3-kinase activity associated with the type I TGF-beta receptor