◀ Back to PI3

PI3 — PLAU

Text-mined interactions from Literome

Sliva et al., J Biol Chem 2002 (Breast Neoplasms...) : Furthermore, inhibition of NF-kappaB markedly attenuated endogenous migration, and inhibition of PI 3-kinase and NF-kappaB reduced secretion of uPA
Mochizuki et al., Oncogene 2002 : Stable expression of activated mutant p110alpha catalytic subunit of PI3-kinase into IBE cells decreased FGF-2 mediated uPA production, suggesting that PI3-kinase exhibited the negative regulatory effect on uPA production ... Taken together, activation of PI3-kinase by FGF-2 is Ras dependent and results in down-regulation of uPA production
Das et al., J Biol Chem 2003 (Breast Neoplasms) : To our knowledge, this is first report that OPN induces NFkappaB activity and uPA secretion by activating PI 3'-kinase/Akt/IKK mediated signaling pathways and further demonstrates a functional molecular link between OPN induced PI 3'-kinase dependent Akt phosphorylation and NFkappaB mediated uPA secretion, and all of these ultimately control the motility of breast cancer cells
Das et al., IUBMB Life 2005 (Disease Progression...) : Taken together, OPN induces NFkappaB activity and uPA secretion by activating PI 3'-kinase/Akt/IKK mediated signaling pathways and further demonstrates a functional molecular link between OPN induced PI 3'-kinase dependent Akt phosphorylation and NFkappaB mediated uPA secretion, and all of these ultimately control the motility and invasiveness of breast cancer cells