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MAP2K1 — PI3

Text-mined interactions from Literome

King et al., Mol Cell Biol 1997 : We conclude that integrin mediated adhesion to fibronectin results in the accumulation of the PI 3-kinase products PI ( 3,4 ) P2 and PI ( 3,4,5 ) P3 as well as the PI 3-kinase dependent activation of the kinases Raf-1, Mek-1 , Erk-2, and AKT and that PI 3-kinase may function upstream of Raf-1 but downstream of Ras in integrin activation of Erk-2 MAP and AKT kinases
Eder et al., J Biol Chem 1998 : Furthermore, in normal T cells, inhibition of PI 3-kinase prevented activation of enzymes in the extracellular signal regulated protein kinase ( ERK ) signaling pathway ( MEK-1 and ERK-2 )