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CXCL12 — PI3
Text-mined interactions from Literome
Kanda et al., J Biol Chem 2003
:
SDF-1alpha activated
PI3-kinase in IBE cells ... Taken together,
SDF-1alpha induces compact cell-cell contact through
PI3-kinase , resulting in tube formation of endothelial cells
Curnock et al., J Immunol 2003
:
In this study Jurkat clones were established, stably expressing dominant negative constructs of class IA and class IB PI 3-kinases under the control of the tetracycline off inducible gene system, to determine the relative
roles of these
PI 3-kinases in
SDF-1 signaling
Fernandis et al., Oncogene 2004
(Breast Neoplasms...) :
CXCL12 induced the activation of
PI 3-kinase , and increased its association with Cbl and SHP2
Lee et al., Mol Cancer Res 2004
(Breast Neoplasms...) :
Stromal cell derived factor 1alpha ( SDF-1alpha ; CXCL12 ) stimulation of breast cancer cells
resulted in
phosphoinositide 3-kinase (PI-3K) activation, AKT phosphorylation, and activation of the FKHRL1 transcription factor
Gálvez et al., J Biol Chem 2005
:
Investigation of the signaling pathways involved in chemokine induced MT1-MMP activity in ECs revealed that CCL2 and
CXCL8 induced cortical actin polymerization and sustained
activation of
phosphatidylinositol 3-kinase (PI3K) and the small GTPase Rac
Li et al., Chin Med J (Engl) 2006
(Endometrial Neoplasms) :
Growth and
activation of
PI-3K/PKB and Akt by
stromal cell derived factor 1alpha in endometrial carcinoma cells with expression of suppressor endoprotein PTEN
Amin et al., Arthritis Rheum 2007
(Arthritis, Rheumatoid) :
IL-18 induced
SDF-1alpha/CXCL12 up-regulation was
dependent on JNK, p38 MAPK,
phosphatidylinositol 3-kinase (PI3K) , and NFkappaB
Sameermahmood et al., Invest Ophthalmol Vis Sci 2008
:
In addition, curcumin significantly ( P < 0.001 ) decreased SDF-1alpha induced HRECs migration and downregulated
SDF-1alpha induced expression of CXCR4, phospho-AKT,
phospho-phosphatidylinositol-3-kinase (PI3-K) , and eNOS
Lin et al., J Biol Chem 2011
:
In this study, we further investigated the
roles of Rac1,
phosphoinositide 3-kinase (PI3K) , and Akt in thrombin induced NF-?B activation and
IL-8/CXCL8 expression
Wang et al., World J Gastroenterol 2011
(Colonic Neoplasms) :
SDF-1 induced phosphorylation of
phosphatidylinositol 3-kinase (PI3K)/AKT and ß-catenin was detected by Western blotting