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AHR — TP53

Text-mined interactions from Literome

Jeffy et al., Neoplasia (New York, N.Y.) 2000 (Adenocarcinoma...) : These findings suggest that the AhR mediated the inverse expression patterns of BRCA-1 and p53 upon exposure to B [ a ] P
Ray et al., J Biol Chem 2004 : Here, we show that repression of p16(INK4a) and p53 transcriptional activity by dioxin absolutely requires the AHR and is accompanied by promoter methylation
Gao et al., Mol Pharmacol 2008 : These results suggest that DMBA activates p53 in a CYP1B1- and mEH dependent manner in vivo but is not AhR dependent
Vondrácek et al., Environ Toxicol Chem 2007 : We then investigated their aryl hydrocarbon receptor (AhR) mediated activity, accumulation of phosphorylated p53 protein, induction of expression of cytochrome P450 1A1 (CYP1A1), inhibition of gap junctional intercellular communication ( GJIC ), and effects on cell proliferation in rat liver cell models to evaluate the relative importance of these toxicity mechanisms of low-molecular-weight methylated PAHs
Reyes-Hernández et al., Biochem Pharmacol 2010 : On the other hand, AhR activation increases Ube2l3 mRNA and protein levels by controlling Ube2l3 gene expression, resulting in increased p53 ubiquitination and degradation
Volkova et al., Cardiovasc Res 2011 : Moreover, lack of AhR in vivo resulted in a significant decrease in left ventricular function compared with wild-type animals, and increased p53 activation and apoptosis in the heart after treatment with DOX