Gene interactions and pathways from curated databases and text-mining

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MAPK3 — PBK

Text-mined interactions from Literome

Duan et al., Exp Cell Res 2004 : It is suggested that PI3K and ERK/MAPK mediated the activation of SPK and would be involved in the HGF induced migration of endothelial cells
Wu et al., Mol Cell Biol 2004 : Inhibition of SPK by the pharmacological inhibitor N, N-dimethylsphingosine ( DMS ) or SPK1-specific siRNA blocked LPS stimulation of extracellular signal regulated kinase 1/2 and p38 but enhanced LPS induced c-Jun N-terminal kinase activation