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PRKAR2A — RAF1

Text-mined interactions from Literome

MacNicol et al., J Biol Chem 1999 : PKA can both prevent Ras dependent Raf-1 activation and directly inhibit Raf-1 catalytic activity ... This potentiation, rather than inhibition, of PC12 cell differentiation is curious in light of the ability of PKA to inhibit Raf-1 catalytic activity
Dhillon et al., Mol Cell Biol 2002 : The cyclic AMP ( cAMP ) -dependent protein kinase (PKA) can inhibit Raf-1 by direct phosphorylation ... cAMP increased Raf-1 serine 259 phosphorylation in a PKA dependent manner with kinetics that correlated with ERK deactivation ... Using RafS259 mutants we also demonstrate that Raf-1 is the sole target for PKA inhibition of ERK and ERK induced gene expression, and that Raf-1 inhibition is mediated mainly through serine 259 phosphorylation
Puana et al., Anesth Analg 2008 : Cyclic adenosine monophosphate inhibits the phosphoinositide/MAP kinase hyperpermeability pathway via the protein kinase A (PKA) dependent inhibition of Raf-1
Lai et al., Cell Biochem Funct 2009 : Our results suggest that rapid PTH inhibition of ERK1/2 activity is mediated by PKA dependent inhibition of c-Raf activity and that stimulation of MKP-1 may contribute to maintaining pERK1/2 inhibition over prolonged time
Spirli et al., Hepatology 2012 (Cysts...) : These effects are consistent with the ability of Raf inhibitors to transactivate Raf-1 when a PKA activated Ras promotes Raf-1/B-Raf heterodimerization, and are inhibited by interfering with cAMP/PKA signaling both in vitro and in vivo, as shown by the reduction of liver cysts in mice treated with combined octreotide and sorafenib
Mischak et al., Mol Cell Biol 1996 : As the binding to GTP loaded Ras induces Raf-1 activation in the cell, we examined which mechanism is required for PKA mediated Raf-1 inhibition in vivo
Fishman et al., Cancer Res 1997 (Fibrosarcoma...) : However, based on the discovery that activated PKA may inhibit ras mediated translocation of c-Raf-1 to the plasma membrane, it is generally accepted that the cross-talk between cAMP/PKA and p21ras mediated signal transduction pathways is unilateral, i.e., that the activation of PKA regulates growth factor receptor protein tyrosine kinase mediated signaling
Hu et al., J Biol Chem 1999 : These results indicate that the CRR binding activity and the Ras-suppressive function of Rap1A can be modulated through phosphorylation and suggest that Rap1A may function as a PKA dependent regulator of Raf-1 activation, not merely as a suppressor