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NOS3 — RHOA
Text-mined interactions from Literome
Eto et al., Circ Res 2001
:
Inhibition of
Rho A by C3 exoenzyme ( 20 microgram/mL ) and ROCK by Y-27632 ( 10 micromol/L )
prevented the downregulation of
eNOS expression by thrombin
Ming et al., Mol Cell Biol 2002
:
Using adenovirus mediated gene transfer in human umbilical vein endothelial cells ( HUVECs ), we show here that both active
RhoA and ROCK not only downregulate eNOS gene expression as reported previously but also
inhibit eNOS phosphorylation at Ser-1177 and cellular NO production with concomitant suppression of PKB activation ... Moreover, coexpression of a constitutive active form of PKB restores the phosphorylation but not gene expression of
eNOS in the
presence of active
RhoA
Barandier et al., Biochem Biophys Res Commun 2003
:
We showed that expression of constitutively active
RhoA ( Rho63 ) or ROCK ( CAT )
suppressed eNOS gene expression
Rattan et al., Free Radic Biol Med 2003
:
Rho A negatively
regulates cytokine mediated inducible
nitric oxide synthase expression in brain derived transformed cell lines : negative regulation of IKKalpha
Viswambharan et al., Circ Res 2004
:
In conclusion, rHDL inhibits thrombin induced human endothelial TF expression through inhibition of
RhoA and
activation of PI3K but not
Akt/eNOS
Bivalacqua et al., Proc Natl Acad Sci U S A 2004
(Body Weight...) :
RhoA/Rho-kinase suppresses endothelial
nitric oxide synthase in the penis : a mechanism for diabetes associated erectile dysfunction ...
RhoA/Rho-kinase may
suppress endothelial nitric oxide synthase (eNOS) ... Here, we tested the hypothesis that
RhoA/Rho-kinase contributes to diabetes related erectile dysfunction and down-regulation of
eNOS in the streptozotocin (STZ)-diabetic rat penis
Liao et al., J Investig Med 2004
(Cardiomegaly...) :
Furthermore, inhibition of
RhoA by statins
leads to the activation of protein kinase B/Akt and up-regulation of endothelial
nitric oxide synthase in the endothelium and the heart
Mital et al., Semin Vasc Med 2004
(Cardiomegaly) :
Furthermore, inhibition of
RhoA by statins
leads to the activation of protein kinase B/Akt and upregulation of Type 3
nitric oxide synthase in the endothelium and the heart
Jin et al., Neurosci Lett 2006
:
Hypoxia induced upregulation of endothelial small G protein
RhoA and Rho-kinase/ROCK2
inhibits eNOS expression ... Using the human endothelial cell line HUVEC, the present study investigated the
role of
RhoA and Rho-kinase in endothelial
eNOS protein expression under hypoxic conditions as an in vitro model of ischemia ... The hypoxia induced decrease in
eNOS expression was significantly
enhanced by expression of the constitutively active form of
RhoA and significantly inhibited by suppression of RhoA expression by small interfering RNA ... Since expression and activation of
RhoA and Rho-kinase
inhibit eNOS expression in endothelial cells, attempts to down-regulate RhoA and Rho-kinase by multiple drugs, such as statins or Rho-kinase inhibitors, might provide endothelial and cardiovascular benefits through upregulation of eNOS
Trebicka et al., Hepatology 2007
(Liver Cirrhosis) :
Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of
RhoA/Rho-kinase and
activation of endothelial
nitric oxide synthase
Soliman et al., Cardiovasc Res 2008
(Diabetes Mellitus, Experimental...) :
Role of inducible
nitric oxide synthase in induction of
RhoA expression in hearts from diabetic rats
Sawada et al., Expert Rev Neurother 2009
(Stroke) :
The upregulation of
eNOS by statins is
mediated by inhibition of small GTP binding protein
RhoA