◀ Back to MITF

ATF1 — MITF

Text-mined interactions from Literome

Li et al., Br J Cancer 2003 (Sarcoma...) : Melanocyte-specific expression of Mitf-M is achieved via an ATF dependent melanocyte-specific cAMP-response element in the Mitf-M promoter, and expression of Mitf-M in CCS cells suggests that EWS/ATF1 ( a potent and promiscuous activator of cAMP-inducible promoters ) may activate the Mitf-M promoter ... Surprisingly, however, the Mitf-M promoter is not activated by EWS/ATF1 in transient assays employing CCS cells, melanocytes or nonmelanocytic cells ... Thus, our results indicate that Mitf-M promoter activation may require an appropriate chromosomal context in CCS cells or alternatively that the Mitf-M promoter is not directly activated by EWS/ATF1
Hallor et al., Genes Chromosomes Cancer 2005 (Adenocarcinoma, Clear Cell...) : Simultaneous expression of the EWSR1-ATF1 and MITF-M transcripts in CCS has led to the proposal that the MITF-M promoter is transactivated by EWSR1-ATF1
Davis et al., Cancer Res 2010 (Sarcoma, Clear Cell) : EWS-ATF1 activates the melanocyte transcription factor MITF , which in turn activates transcription of c-Met, an oncogenic receptor tyrosine kinase recently shown to be activated in CCS