◀ Back to MAPK1

MAPK1 — SFTPC

Text-mined interactions from Literome

Mathieson et al., Br J Pharmacol 2006 : In contrast, SPC increased p38MAPK phosphorylation ( 3.0+/-0.3-fold increase ) but did not stimulate ERK1/2 ... CREB activation by SPC required both p38MAPK and CaMK activation, but not ERK1/2
Wirrig et al., J Cereb Blood Flow Metab 2011 (Inflammation...) : Both these transcription factors were activated by SPC in a p38MAPK dependent manner
Bitar et al., Am J Physiol 1995 : SPC also induced activation of mitogen activated protein kinase ( MAP kinase )
Seufferlein et al., J Biol Chem 1995 : SPC induced p42MAPK activation peaked at 5 min and was undetectable after 30 min of incubation with SPC ... The effect of SPC on p42MAPK activation was comparable to that induced by bombesin and platelet derived growth factor ... As SPC strongly induced phosphorylation of the major protein kinase C ( PKC ) substrate 80K/MARCKS in either intact or permeabilized cells, we examined whether PKC could be involved in SPC induced p42MAPK activation ... Here, we demonstrate that p42MAPK activation by SPC was dependent on PKC activity as shown by inhibition of PKC with the bisindolymaleimide GF 109203X or down-regulation of PKC by prolonged treatment of Swiss 3T3 cells with phorbol esters ... Activation of both PKC and p42MAPK by SPC was markedly inhibited by treatment with pertussis toxin, implicating a G proteins ( s ) of the Gi/G ( o ) subfamily in the action of SPC ... SPC also induced p42MAPK activation and DNA synthesis in secondary cultures of mouse embryo fibroblasts through a pertussis toxin-sensitive pathway
Chin et al., Am J Physiol 1998 : In addition, SPC stimulated the mitogen activated protein kinase ( MAPK ) and increased DNA synthesis, whereas neither ATP nor BK produced such effects ... Both the SPC induced MAPK activation and DNA synthesis were pertussis toxin sensitive ... SPC induced MAPK activation was blocked by treatment of cells with the phospholipase C inhibitor, U-73122, or the intracellular Ca2+-ATPase inhibitor, thapsigargin, but not by removal of extracellular Ca2+ ... Platelet derived growth factor ( PDGF ) also induced a [Ca2+ ] i increase, MAPK activation, and DNA synthesis in the same cells ; however, the PDGF induced MAPK activation was not sensitive to pertussis toxin and changes in [Ca2+ ] i. SPC induced MAPK activation was inhibited by pretreatment of cells with staurosporine, W-7, or calmidazolium
Imokawa et al., J Invest Dermatol 1999 : Assay of mitogen activated protein kinase revealed that 10 microM SPC induced a rapid activation of mitogen activated protein kinase in human keratinocytes, including an increase in its phosphorylation within 5 min, which then declined to the baseline control level after 30 min