UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

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HCK — ITGAM

Pathways - manually collected, often from reviews:

NCI Pathway Database amb2 Integrin signaling: Hck (HCK) → alphaM/beta2 Integrin complex (ITGAM-ITGB2) (modification, collaborate)
Tang et al., FEBS Lett 2006 *
Evidence: expresssion pattern, physical interaction
NCI Pathway Database amb2 Integrin signaling: Hck (HCK) → alphaM/beta2 Integrin/Hck complex (ITGAM-ITGB2-HCK) (modification, collaborate)
Tang et al., FEBS Lett 2006 *
Evidence: expresssion pattern, physical interaction
NCI Pathway Database amb2 Integrin signaling: alphaM/beta2 Integrin complex (ITGAM-ITGB2) → alphaM/beta2 Integrin/Hck complex (ITGAM-ITGB2-HCK) (modification, collaborate)
Tang et al., FEBS Lett 2006 *
Evidence: expresssion pattern, physical interaction
NCI Pathway Database amb2 Integrin signaling: alphaM/beta2 Integrin/P-Selectin/PSGL1 complex (ITGAM-ITGB2-SELPLG-SELP) → Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (leukocyte adhesion, collaborate)
Piccardoni et al., Blood 2001
Evidence: mutant phenotype, assay