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FGF14 — FRS2
Text-mined interactions from Literome
Gotoh et al., Proc Natl Acad Sci U S A 2004
:
Consistent with the critical
role of
FRS2alpha in
FGF signaling, the level of activated extracellular signal regulated kinase in Frs2alpha ( 2F/2F ) embryos was significantly lower than that observed in wild-type embryos
Zhou et al., Cell Res 2009
:
Recent studies have shown that mitogen activated protein kinase ( MAPK ) phosphorylates serine and threonine residues in FRS2, negatively affecting
FGF induced tyrosine phosphorylation ( PY ) of
FRS2
Haling et al., Mol Biol Cell 2010
(MAP Kinase Signaling System) :
This reduced threonine phosphorylation led to increased
FGF induced tyrosine phosphorylation of
FRS2alpha , thereby enhancing downstream signaling
Lin et al., International journal of biological sciences 2011
:
FRS2a is
essential for the
fibroblast growth factor to regulate the mTOR pathway and autophagy in mouse embryonic fibroblasts
Huynh et al., J Hepatol 2012
(Carcinoma, Hepatocellular...) :
Dovitinib inhibited basal expression and
FGF induced phosphorylation of FGFR-1,
FRS2-a and ERK1/2 ... Dovitinib inhibited basal expression and
FGF induced phosphorylation of FGFR-1,
FRS2-a and ERK1/2
Zhang et al., Circ Res 2012
:
FRS2a mediated
FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity
Madakashira et al., Development 2012
:
Frs2a enhances
fibroblast growth factor mediated survival and differentiation in lens development
Hadari et al., Mol Cell Biol 1998
:
Binding of Shp2 tyrosine phosphatase to
FRS2 is
essential for
fibroblast growth factor induced PC12 cell differentiation ... In this report, we demonstrate that
FRS2 forms a complex with the N-terminal SH2 domain of the protein tyrosine phosphatase Shp2 in
response to
FGF stimulation