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IL18 — MMP2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MMP2 → IL18 (increases, IL18 Translocation) Chandrasekar et al., J Biol Chem 2006*
  Evidence: The results indicate that, although IL-18 stimulated secretion of the gelatinases MMP2 and MMP9, it had no significant effect on other MMPs or on TIMPs, suggesting that IL-18 induces matrix degradation by up-regulating MMP2 and MMP9 (Fig. 2).

Text-mined interactions from Literome

Meisser et al., Mol Hum Reprod 1999 : The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Abraham et al., Int Immunol 2002 : The present study examined differential effects of pro-inflammatory [IL-18 , IL-12 and tumor necrosis factor (TNF)-alpha ] versus anti-inflammatory ( IL-4 ) cytokines on the modulation of MMP and their endogenous tissue inhibitors ( TIMP ) expression in the U937 cell line ... IL-18 and IL-12 separately and synergistically enhanced MMP-2 , while TNF-alpha led to the elevation of MMP-9
Sun et al., Connect Tissue Res 2003 (Arthritis, Rheumatoid) : Furthermore, the induction of the MMP expression and activities by interleukin-1 was suppressed by the oscillatory shear
Zhang et al., Leuk Res 2004 (Leukemia, Myeloid...) : Moreover, IL-18 could significantly increase MMP-9 but not MMP-2 production at both mRNA and/or protein level, slightly up-regulate TIMP-1 mRNA, and clearly induce TIMP-2 mRNA secretion
Ishida et al., FEBS Lett 2004 : As well, IL-18 stimulation induces the production of activated forms of matrix metalloproteinase-2 (MMP-2) as well as the production of pro-MMP-2 from NK cells
Dai et al., Ann Rheum Dis 2005 (Arthritis...) : In chondrocytes responding to IL18, IL18 ( 1-100 ng/ml ) slightly increased the production of MMP-1, MMP-3 , and MMP-13, which was blocked by NF-kappaB inhibitor and p38 mitogen activated protein kinase inhibitor
Chandrasekar et al., J Biol Chem 2006 (Atherosclerosis) : Because we demonstrated previously that the proinflammatory and proatherogenic cytokine interleukin-18 (IL-18) stimulates SMC proliferation ( Chandrasekar, B., Mummidi, S., Valente, A. J., Patel, D. N., Bailey, S. R., Freeman, G. L., Hatano, M., Tokuhisa, T., and Jensen, L. E. ( 2005 ) J. Biol. Chem. 280, 26263-26277 ), we investigated whether IL-18 induces SMC migration in an MMP dependent manner and whether the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin can inhibit this response
Salamonsen et al., Hum Reprod 1996 : Progesterone withdrawal from stromal cell cultures ( for the final 4 days of a 10 day culture ) increased the release of all four enzymes : all but MMP-2 were also stimulated by interleukin-1 or tumour necrosis factor alpha added to short-term stromal cultures