◀ Back to LEP

APOM — LEP

Text-mined interactions from Literome

Xu et al., Biochem Biophys Res Commun 2004 : Both leptin and leptin-receptor are essential for apolipoprotein M expression in vivo ... We conclude that both leptin and leptin-receptor are essential for the apoM expression, indicating that leptin is physiologically regulating apoM synthesis in vivo
Luo et al., Lipids in health and disease 2004 : Expression of apoM could be regulated by platelet activating factor (PAF), transforming growth factors ( TGF ), insulin-like growth factor (IGF) and leptin in vivo and/or in vitro
Luo et al., Biochim Biophys Acta 2005 (Carcinoma, Hepatocellular...) : Leptin inhibits apolipoprotein M transcription and secretion in human hepatoma cell line, HepG2 cells ... Previously we have reported that both leptin and leptin receptor are essential for apoM expression in vivo ... The inhibitory effect of leptin on apoM mRNA levels in HepG2 cells is dose dependent, i.e. 100 ng/mL of leptin decreased apoM mRNA levels by 30 %, and 500 ng/mL of leptin decreased apoM mRNA levels about 50 % ... The mechanism on the contradictory effects of leptin on apoM expression in vivo and in vitro needs further investigation