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HEY2 — NOTCH2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Donovan et al., Curr Biol 2002
(Heart Defects, Congenital...) :
These results establish Hey2 as an important regulator of cardiac morphogenesis and suggest a
role for
Hey2 in mediating or modulating
Notch signaling in the developing heart
Rutenberg et al., Development 2006
:
Misactivation or inhibition of
Notch2 specifically induced or inhibited Hey1, respectively, but these manipulations did not
affect Hey2 , implicating Hey1 as the direct mediator of Notch2
Kokubo et al., Development 2007
:
Furthermore, we find that the expression of Hesr1 and
Hesr2 is
independent of
Notch2 signaling
Rowlinson et al., Blood 2010
:
Whereas knockdown of
Hey2 expression
results in a loss of
Notch receptor expression in dorsal aorta angioblasts, activation of Notch signaling in hey2 morphants rescues HSC formation in zebrafish embryos