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RAC1 — TIAM2

Pathways - manually collected, often from reviews:

• KEGG Regulation of actin cytoskeleton: TIAM1/TIAM2/VAV1/VAV2/VAV3 → RAC1/RAC2/RAC3 (protein-protein, activation)
• KEGG Chemokine signaling pathway: TIAM1/TIAM2 → RAC1/RAC2 (protein-protein, activation)
• NCI Pathway Database Regulation of RAC1 activity: RAC1/GDP complex (RAC1) → Tiam2 (TIAM2) (modification, collaborate) Hoshino et al., J Biol Chem 1999*, Matsuo et al., J Biol Chem 2002*, Takefuji et al., Biochem Biophys Res Commun 2007*
  Evidence: assay
• Reactome Reaction: RAC1 → TIAM2 (reaction) Harrington et al., J Neurosci 2002
• WikiPathways Chemokine signaling pathway: TIAM1/TIAM2 → RAC1/RAC2 (activation)

Text-mined interactions from Literome

Rivard et al., Frontiers in bioscience (Landmark edition) 2009 : PKB/Akt may be involved in the regulation of survival and proliferation while Tiam and Vav may activate Rac , resulting in reorganization of actin cytoskeleton which ultimately serves to mediate adhesive cell-cell recognition as well as epithelial cell differentiation and polarity
Goto et al., Mol Biol Cell 2011 : Phosphorylation of STEF/Tiam2 by protein kinase A is critical for Rac1 activation and neurite outgrowth in dibutyryl cAMP treated PC12D cells ... dbcAMP induced Rac1 activation was principally mediated by protein kinase A (PKA) and Sif- and Tiam1-like exchange factor ( STEF ) /Tiam2
Lim et al., Biol Cell 2012 : We also summarise studies into outside-in signalling, focussing on the roles of RhoA and RhoG, and activation of Rac1 through the complex comprising TIAM , 14-3-3 and ß2