Pelletier et al., Mol Cell Biol 2003
:
Expression of activated mutants of Rac1 is sufficient to activate Jak2 and STAT dependent transcription, and the activation of Jak2 correlates with the ability of Rac1 to bind to NADPH oxidase subunit p67(phox)
Lopez-Haber et al., Mol Pharmacol 2013
(Breast Neoplasms) :
However, Rac1 activation was not affected by Jak2 or Stat3 RNA interference, suggesting that the effect of cucurbitacin I occurs through a Jak2 independent mechanism