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MAP3K14 — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAP3K14 → TNF (increases, TNF Activity) Kougias et al., J Surg Res 2005*
  Evidence: The mechanism of adiponectin action in endothelial cells has been further investigated. TNF-A activates nuclear transcription factor NF-KB in these cells by stimulating protein kinase NIK (NF-kB inducing kinase), which phosphorylates the NF-kB inhibitor, IkB, initiating its degradation and thus leading to NF-KB activation. NF-KB stimulates the expression of cytokines and adhesion molecules involved in the inflammatory process.
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) → NIK (MAP3K14) (modification, activates) Malinin et al., Nature 1997

Text-mined interactions from Literome

Chen et al., Mol Pharmacol 2001 : TNF-alpha- or C2-ceramide induced COX-2 promoter activity was inhibited by the dominant negative mutant of extracellular signal regulated kinase 2, p38, JNK, IkappaB kinase (IKK)1 , or IKK2
Tu et al., J Immunol 2001 : TNF-alpha induces activation of inhibitor of NF-kappaB (IkappaB) kinase-beta ( IKK-beta ), a protein kinase that phosphorylates the NF-kappaB inhibitor IkappaB, and thereby targets the latter for degradation via the ubiquitin-proteasome pathway
Zhang et al., FASEB J 2001 : Furthermore, LA dose-dependently inhibited TNF-alpha induced IkappaB kinase activation , subsequent degradation of IkappaB, the cytoplasmic NF-kappaB inhibitor, and nuclear translocation of NF-kappaB
Chen et al., Inflammation 2002 : In addition, EGCG inhibited TNF-alpha mediated activation of IkappaB kinase and subsequent activation of the IkappaB alpha/NF-kappaB pathway
Tang et al., J Biol Chem 2003 : A role for NF-kappaB essential modifier/IkappaB kinase-gamma ( NEMO/IKKgamma ) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha
Lee et al., J Biol Chem 2004 : The kinase activity of Rip1 is not required for tumor necrosis factor-alpha induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2
Peng et al., J Leukoc Biol 2005 : Here, we demonstrated that inhibition of inhibitor of kappaB (IkappaB) kinase ( IKK ) by a peptide IKK inhibitor or by four individual chemical IKK inhibitors including 15-deoxy-prostaglandin J ( 2 ), BMS-345541, SC-514, or sulindac significantly blocked IgE + trinitrophenyl ( TNP ) -induced TNF production by mouse bone marrow derived MC ( BMMC )
Cusson-Hermance et al., J Biol Chem 2005 : Rip1 is required for IkappaB kinase activation in response to tumor necrosis factor alpha (TNF-alpha) and has been implicated in the Toll-like receptor 3 (TLR3) response to double stranded RNA
Xie et al., Toxicological sciences : an official journal of the Society of Toxicology 2006 : The activity of tumor necrosis factor-alpha induced inhibitor of kappa B (IkappaB) kinase alpha was also inhibited by Cd
Huang et al., Int J Cardiol 2009 (Atherosclerosis) : Metformin inhibits TNF-alpha induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K dependent AMPK phosphorylation
Tsutsui et al., Bioorg Med Chem Lett 2009 (Inflammation) : Consistent with these results, peperomin E and 2,6-didehydropeperomin B blocked the TNF-alpha induced activation of IkappaB kinase , while they had no direct effect on the IkappaB kinase activity
Funakoshi-Tago et al., Mol Pharmacol 2009 : Whereas licochalcone A had no effect on the recruitment of receptor interacting protein 1 and IkappaB kinase beta (IKKbeta) to TNF receptor I by TNF-alpha, it significantly inhibited TNF-alpha induced IkappaB kinase complex (IKK) activation and inhibitor of nuclear factor-kappaB degradation
Liu et al., Proc Natl Acad Sci U S A 2009 : Neither JNK1 activation by IL-1beta or UV nor TNF-alpha induced activation of p38, ERK, or IkappaB kinase complex is affected by the loss of Miz1