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CPZ — TNF
Text-mined interactions from Literome
Tukov et al., Toxicol In Vitro 2006
(Inflammation) :
CPZ alone
caused a concentration dependent increase in
TNF-alpha release, which was approximately additive in the presence of LPS
Gadina et al., J Exp Med 1991
(Shock, Septic) :
It was found that
CPZ protects mice, normal or adrenalectomized, and guinea pigs against lethality of LPS, and
inhibited TNF serum levels, like dexamethasone ( DEX ), a well-known inhibitor of TNF synthesis
Erroi et al., Eur Cytokine Netw 1995
(Dermatitis, Irritant...) :
Chlorpromazine (CPZ) , an inhibitor of TNF synthesis, protected against IR and
inhibited the IR-associated
TNF induction in ear homogenates
Mengozzi et al., Immunology 1994
:
We have previously shown that
chlorpromazine (CPZ) inhibits
tumour necrosis factor (TNF) production and protects against endotoxic shock in mice ... Both DEX and
CPZ inhibited
TNF production, whereas induction of IL-1 and IL-6 was inhibited by DEX but not by CPZ ...
CPZ also
inhibited spleen associated
TNF induction in LPS treated mice, suggesting an effect on the synthesis of TNF ...
CPZ inhibited
TNF induction by Gram positive bacteria ( heat killed Staphylococcus epidermidis ) and by anti-CD3 monoclonal antibodies ...
CPZ inhibited
TNF production in vivo, irrespective of the TNF stimulus used to induce TNF ... Finally,
CPZ did not induce the ` rebound ' effect of DEX that, when given 24 hr before LPS, potentiates TNF production, but it did
inhibit TNF production after 24 hr
Bertini et al., Immunology 1993
:
Chlorpromazine (CPZ) was shown to
inhibit tumour necrosis factor (TNF) production in vivo
Zinetti et al., Immunology 1995
(Leukemia) :
CPZ ( 1-100 microM )
inhibited TNF-alpha production in THP-1 cells in a dose dependent manner by a maximum of 80 % ... On the other hand
CPZ ( 10-25 microM ) also
inhibited TNF-alpha activity : in fact it reduced the cytotoxicity of TNF-alpha on L929 cells ( EC50 was increased four times ) and could provide protection even as a post-treatment
Ikeda et al., Immunol Lett 1997
:
CPZ down-regulated
tumor necrosis factor-alpha (TNF-alpha) and up-regulated IL-10 in mice that then received ConA, whereas delayed administration of CPZ had no effect