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BMP2 — TGFB1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Sanyal et al., J Orthop Res 1999
:
The upregulation of
bone morphogenetic protein-2 mRNA expression was also
enhanced by exogenously added
transforming growth factor-beta1 in the presence of fetal calf serum
Li et al., J Spinal Disord Tech 2004
:
BMP-2 significantly
increased transforming growth factor-beta1 ( TGFbeta1 ) and BMP-7 mRNA expression 2.32 and 2.45 times, respectively, compared with control
Kawaguchi et al., Spine (Phila Pa 1976) 1992
(Ossification, Heterotopic) :
It is suggested that bone morphogenetic protein-2 and
transforming growth factor-beta play important roles in the development of ossification of the posterior longitudinal ligament and that
bone morphogenetic protein-2 may
act as an initiating factor in the development of ossification of the posterior longitudinal ligament by stimulating differentiation of mesenchymal progenitor cells
Singhatanadgit et al., Int J Biochem Cell Biol 2008
:
The
TGF-beta1 induced increase in surface BMPR-IB
resulted in significantly elevated
BMP-2 binding and Smad1/5/8 phosphorylation, although the receptor was subsequently internalised and the functional response to BMP-2 consequently down-regulated
Sharp et al., Ann Biomed Eng 2009
(Mechanotransduction, Cellular) :
In addition, expression of
BMP-2 and -7 were enhanced and
TGF-beta1 suppressed by pulsatile flow relative to steady flow
Murakami et al., Genes Cells 2009
:
In untransfected B16 melanoma cells, TGF-beta1 and
BMP-2 induced phosphorylation of both R-Smad subclasses, and
TGF-beta1 up-regulated the inhibitor of differentiation ( Id ) gene, which is usually regulated by BMP
Harris et al., J Bone Miner Res 1994
:
Effects of
transforming growth factor beta on bone nodule formation and expression of
bone morphogenetic protein 2 , osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts
Zheng et al., J Cell Physiol 1994
:
Recombinant human
bone morphogenetic protein-2 enhances expression of interleukin-6 and
transforming growth factor-beta 1 genes in normal human osteoblast-like cells
Origuchi et al., In Vivo 1998
:
In particular,
TGF-beta 1 appeared to strongly regulate immature stage and
BMP-2/-4 may
regulate the mature stage