Hsieh et al., Am J Pathol 2007
(Hemorrhage...) :
We found that suppression of GPR30 but not ER-alpha prevented E2-BSA- or E2-induced PKA activation and Bcl-2 expression
Ding et al., Am J Physiol Cell Physiol 2009
:
Thus the effect of estradiol on vascular smooth muscle cell apoptosis is likely dependent on the balance between ER-mediated PKA activation and GPR30 mediated PKA inhibition and PI3 kinase activation