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IARS — IGF2

Text-mined interactions from Literome

Tsuruzoe et al., Mol Cell Biol 2001 (MAP Kinase Signaling System) : In these cell lines, IGF-1 caused the rapid tyrosine phosphorylation of all four IRS proteins
Kim et al., Endocrinology 2005 (Neuroblastoma) : In summary, 1 ) IRS-2 is more sensitive to IGF-I mediated degradation ; 2 ) IRS degradation is mediated by phosphatidylinositol 3-kinase and proteasome sensitive pathways ; and 3 ) high levels of IGF-IR , and possibly the subsequent increase in Akt phosphorylation, are required for efficient IRS degradation
Becker et al., Mol Endocrinol 2011 (Breast Neoplasms) : Although rapamycin induced mTOR inhibition has been shown to block IGF induced IRS degradation, we reveal differential effects on motility ( up-regulation ) and proliferation ( down-regulation )