Lee et al., Nature 2000
(Alzheimer Disease) :
Specific inhibitors of calpain , a calcium dependent cysteine protease, effectively inhibit the calcium induced cleavage of p35 de Thonel et al., Mol Biol Cell 2010
:
PKCzeta mediated phosphorylation of Ser-33 on p35 promoted calpain mediated cleavage of p35 to its more active and stable fragment, p25