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DUSP5 — MAPK3

Pathways - manually collected, often from reviews:

• KEGG MAPK signaling pathway: DUSP1/DUSP10/DUSP14/DUSP16/DUSP2/DUSP22/DUSP3/DUSP4/DUSP5/DUSP6/DUSP7/DUSP8/DUSP9 → MAPK1/MAPK3 (protein-protein, inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MAPK3 — DUSP5 (direct interaction, enzymatic study) Kwak et al., J Biol Chem 1995*
• IRef Hprd Interaction: MAPK3 — DUSP5 (in vitro) Kwak et al., J Biol Chem 1995*
• IRef Ophid Interaction: MAPK3 — DUSP5 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: MAPK3 — DUSP5 (aggregation, confirmational text mining) Kwak et al., J Biol Chem 1995*

Text-mined interactions from Literome

Kovanen et al., J Biol Chem 2003 (MAP Kinase Signaling System) : In IL-2 dependent CTLL-2 cells, we show that IL-2 induced ERK-1/2 activity was inhibited by wild type DUSP5 but markedly increased by an inactive form of DUSP5, suggesting a negative feedback role for DUSP5 in IL-2 signaling
Givant-Horwitz et al., Gynecol Oncol 2004 (MAP Kinase Signaling System...) : The objective of the present study was to investigate the expression and clinical role of dual-specificity phosphatases ( DUSP ) , inhibitors of MAPK signaling, in ovarian cancer cells at this site
Kucharska et al., Cell Signal 2009 (MAP Kinase Signaling System) : Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK
Kumabe et al., Microbiol Immunol 2010 : Activation of MAPK is negatively regulated by DUSP , which dephosphorylate the phosphothreonine and phosphotyrosine residues