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DAXX — MDM2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MDM2 — DAXX (direct interaction, pull down) Zhao et al., J Biol Chem 2004*
• IRef Biogrid Interaction: MDM2 — DAXX (physical association, affinity chromatography technology) Tang et al., PloS one 2013*
• IRef Biogrid Interaction: MDM2 — DAXX (physical association, affinity chromatography technology) Zhao et al., J Biol Chem 2004*
• IRef Biogrid Interaction: MDM2 — DAXX (physical association, affinity chromatography technology) Ivanchuk et al., Cell cycle (Georgetown, Tex.) 2008*
• IRef Biogrid Interaction: MDM2 — DAXX (physical association, affinity chromatography technology) Tang et al., Nat Cell Biol 2006
• IRef Biogrid Interaction: MDM2 — DAXX (direct interaction, pull down) Tang et al., Nat Cell Biol 2006
• IRef Biogrid Interaction: MDM2 — DAXX (physical association, affinity chromatography technology) Song et al., EMBO J 2008
• IRef Dip Interaction: MDM2 — DAXX (direct interaction, nuclear magnetic resonance) Escobar-Cabrera et al., Structure 2010*
• IRef Hprd Interaction: DAXX — MDM2 (in vitro) Tang et al., Nat Cell Biol 2006
• IRef Hprd Interaction: DAXX — MDM2 (in vivo) Tang et al., Nat Cell Biol 2006
• IRef Intact Interaction: Complex of 13 proteins (association, anti tag coimmunoprecipitation) Zhao et al., J Biol Chem 2004*
• IRef Intact Interaction: Complex of 17 proteins (association, anti bait coimmunoprecipitation) Tang et al., Nat Cell Biol 2006
• IRef Intact Interaction: Complex of 16 proteins (association, anti bait coimmunoprecipitation) Song et al., EMBO J 2008
• IRef Intact Interaction: Complex of MDM2-RASSF1-DAXX (association, anti bait coimmunoprecipitation) Song et al., EMBO J 2008
• IRef Intact Interaction: Complex of USP7-MDM2-MDM2-MDM2-DAXX-DAXX-USP7-DAXX-USP7 (association, anti tag coimmunoprecipitation) Tang et al., Nat Cell Biol 2006
• IRef Intact Interaction: MDM2 — DAXX (colocalization, fluorescence microscopy) Zhao et al., J Biol Chem 2004*
• IRef Intact Interaction: MDM2 — DAXX (physical association, anti bait coimmunoprecipitation) Tang et al., Nat Cell Biol 2006
• IRef Intact Interaction: MDM2 — DAXX (colocalization, fluorescence technology) Tang et al., Nat Cell Biol 2006
• IRef Intact Interaction: MDM2 — DAXX (physical association, pull down) Tang et al., Nat Cell Biol 2006
• IRef Intact Interaction: MDM2 — DAXX (physical association, anti tag coimmunoprecipitation) Song et al., EMBO J 2008
• IRef Intact Interaction: MDM2 — DAXX (association, anti tag coimmunoprecipitation) Ivanchuk et al., Cell cycle (Georgetown, Tex.) 2008*
• IRef Intact Interaction: MDM2 — DAXX (physical association, display technology) Miyamoto-Sato et al., PloS one 2010
• IRef Intact Interaction: MDM2 — DAXX (physical association, anti tag coimmunoprecipitation) Zhao et al., J Biol Chem 2004*

Text-mined interactions from Literome

Zhao et al., J Biol Chem 2004 : Interestingly, whereas Daxx did not bind to p53 in cells as assessed by immunoprecipitation, MDM2 expression restored p53-Daxx interaction, and this correlated with deacetylation of p53 ... Interestingly, whereas Daxx did not bind to p53 in cells as assessed by immunoprecipitation, MDM2 expression restored p53-Daxx interaction, and this correlated with deacetylation of p53
Tang et al., Nat Cell Biol 2006 : Critical role for Daxx in regulating Mdm2 ... Downregulation of Daxx decreases Mdm2 levels, whereas overexpression of Daxx strongly stabilizes Mdm2 ... Daxx simultaneously binds to Mdm2 and the deubiquitinase Hausp, and it mediates the stabilizing effect of Hausp on Mdm2 ... In addition, Daxx enhances the intrinsic E3 activity of Mdm2 towards p53
Tang et al., Biochem Biophys Res Commun 2010 : Daxx is reciprocally regulated by Mdm2 and Hausp ... In the present work, we show that Daxx is ubiquitinated by Mdm2 in both in vitro and in vivo systems and Mdm2 reduces Daxx expression upon over-expression
Tang et al., PloS one 2013 (Neoplasms) : The optimal function of Mdm2 requires Daxx , which stabilizes Mdm2 through the deubiquitinase Hausp/USP7 and also directly promotes Mdm2 's ubiquitin ligase activity towards p53