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CD28 — IL17A

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IL17A → CD28 (increases) Kim et al., Arthritis Res Ther 2005*
  Evidence: Incubation of PBMCs with 10 microgram/ml anti-CD3 significantly upregulated IL-17 production upto 3.7 fold, and combination of anti-CD3 and anti-CD28 produced more IL-17 (approximately 1.3-1.5 fold) than anti-CD3 alone. Furthermore, treatment with LY294002 and wortmannin, inhibitors of PI3K, and PDTC, NFkB inhibitor markedly blocked the anti-CD3 and anti-CD28 induced IL17 protein and mRNA production in a dose dependent manner. This indicates that CD3 and CD28 induced IL-17 production was mediate...

Text-mined interactions from Literome

Chen et al., Arthritis Rheum 2007 : In response to anti-CD3/anti-CD28 stimulation alone, human memory T cells rapidly produced IL-17 , whereas naive T cells expressed low levels
Naundorf et al., Eur J Immunol 2009 : In contrast, IL-10 did not affect anti-CD3/anti-CD28 induced IL-17 production from memory T cells even in the presence of APC
Dagur et al., J Autoimmun 2011 (Autoimmune Diseases...) : Upon TCR stimulation with CD3/CD28 , CD4 ( + ) CD146 ( + ) T cells secrete significantly more IL-17A , IL-6, and IL-8 than do CD4 ( + ) CD146 ( - ) T cells
Ruiz et al., J Immunol Methods 2012 (Helicobacter Infections) : Following isolation we compared lymphocyte stimulation by CD3/CD28, phorbol 12-myristate 13-acetate ( PMA ) and ionomycin or H. pylori lysate and determined that CD3/CD28 effectively induces stimulation of IFN? and IL 17A , but impairs Foxp3 expression