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CBL — MET

Pathways - manually collected, often from reviews:

• KEGG Endocytosis: CBL/CBLB/CBLC/ITCH/MDM2/NEDD4/NEDD4L/RNF41/SMURF1/SMURF2/TRAF6/WWP1 → CSF1R/EGFR/ERBB3/ERBB4/FGFR2/FGFR3/FGFR4/FLT1/IGF1R/KDR/KIT/MET/NTRK1/PDGFRA/RET (protein-protein, ubiquination)
  
• KEGG Bacterial invasion of epithelial cells: CBL/CBLB/CBLC → MET (protein-protein, ubiquination)
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): CBL(dimer) complex (CBL) → HGF(dimer)/MET(dimer) complex (MET-HGF) (modification, activates)
  Peschard et al., Mol Cell 2001*, Kozlov et al., J Biol Chem 2007*
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): CIN85/Endophilin/CBL complex (SH3KBP1-SH3GL2-CBL) → HGF(dimer)/MET(dimer) complex (MET-HGF) (translocation, activates)
  Petrelli et al., Nature 2002
  Evidence: assay, physical interaction
• WikiPathways Signaling Pathways in Glioblastoma: CBL → IGF1R/ERBB3/FGFR1/PDGFRA/PDGFRB/ERBB2/EGFR/FGFR2/MET (mim-inhibition)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: CBL — MET Petrelli et al., Nature 2002
• IRef Bind_translation Interaction: CBL — MET (coimmunoprecipitation) Petrelli et al., Nature 2002
• IRef Biogrid Interaction: CBL — MET (physical association, affinity chromatography technology) Peschard et al., J Biol Chem 2004*
• IRef Biogrid Interaction: CBL — MET (association, x-ray crystallography) Ng et al., EMBO J 2008
• IRef Biogrid Interaction: CBL — MET (physical association, affinity chromatography technology) Ng et al., EMBO J 2008
• IRef Biogrid Interaction: CBL — MET (direct interaction, pull down) Peschard et al., J Biol Chem 2004*
• IRef Biogrid Interaction: CBL — MET (physical association, affinity chromatography technology) Goldoni et al., J Cell Biol 2009*
• IRef Biogrid Interaction: CBL — MET (direct interaction, pull down) Sun et al., FEBS Lett 2011*
• IRef Biogrid Interaction: CBL — MET (direct interaction, pull down) Hill et al., J Exp Ther Oncol 2010*
• IRef Biogrid Interaction: CBL — MET (association, x-ray crystallography) Sun et al., FEBS Lett 2011*
• IRef Biogrid Interaction: CBL — MET (physical association, affinity chromatography technology) Deheuninck et al., Cell Signal 2009*
• IRef Biogrid Interaction: CBL — MET (direct interaction, enzymatic study) Petrelli et al., Nature 2002
• IRef Biogrid Interaction: CBL — MET (physical association, affinity chromatography technology) Kong-Beltran et al., Cancer Res 2006*
• MIPS CORUM MET-CIN85-SH3GL3-CBL complex, HGF stimulated: MET-CIN85-SH3GL3-CBL complex, HGF stimulated complex (CBL-MET-SH3GL3-SH3KBP1) Petrelli et al., Nature 2002
• IRef Corum Interaction: Complex of MET-CBL-SH3KBP1-SH3GL3 (association, anti bait coimmunoprecipitation) Petrelli et al., Nature 2002
• IRef Hprd Interaction: CBL — MET (in vitro) Petrelli et al., Nature 2002, Ng et al., EMBO J 2008
• IRef Hprd Interaction: CBL — MET (two hybrid) Petrelli et al., Nature 2002, Ng et al., EMBO J 2008
• IRef Hprd Interaction: CBL — MET (in vivo) Petrelli et al., Nature 2002, Ng et al., EMBO J 2008
• IRef Intact Interaction: CBL — MET (ubiquitination reaction, experimental interaction detection) Petrelli et al., Nature 2002
• IRef Intact Interaction: CBL — MET (physical association, coimmunoprecipitation) Petrelli et al., Nature 2002
• IRef Intact Interaction: CBL — MET (direct interaction, isothermal titration calorimetry) Ng et al., EMBO J 2008
• IRef Intact Interaction: CBL — MET (physical association, anti bait coimmunoprecipitation) Ng et al., EMBO J 2008
• IRef Intact Interaction: CBL — MET (direct interaction, x-ray crystallography) Ng et al., EMBO J 2008
• IRef Intact Interaction: CBL — MET (direct interaction, x-ray crystallography) Sun et al., FEBS Lett 2011*
• IRef Intact Interaction: CBL — MET (direct interaction, mass spectrometry studies of complexes) Sun et al., FEBS Lett 2011*
• IRef Intact Interaction: CBL — MET (direct interaction, surface plasmon resonance) Sun et al., FEBS Lett 2011*
• IRef Ophid Interaction: CBL — MET (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Garcia-Guzman et al., Oncogene 2000 (MAP Kinase Signaling System) : Taken together, our studies demonstrate a previously unidentified functional role for Cbl in Met signaling and suggest that Met utilizes at least two docking proteins, Gab1 and Cbl, to activate downstream signaling pathways
Petrelli et al., Nature 2002 : The endophilin-CIN85-Cbl complex mediates ligand dependent downregulation of c-Met ... Cbl, in turn, binds and ubiquitinates activated HGF receptor , and by recruiting the endophilin-CIN85 complex , it regulates receptor internalization ... These data provide further evidence of a relationship between receptor mediated signalling and endocytosis, and disclose a novel functional role for Cbl in HGF receptor signalling
Taher et al., J Immunol 2002 : c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor induced receptor ubiquitination
Mak et al., Oncogene 2007 : In contrast, plasma membrane targeting allows Tpr-Met to enter the endocytic pathway, and Tpr-Met transforming activity as well as protein stability are decreased in a Cbl dependent manner
Lai et al., J Biol Chem 2012 (Stomach Neoplasms) : Met kinase dependent loss of the E3 ligase Cbl in gastric cancer ... Thus, Met dependent Cbl loss may also promote cross-talk through indirect enhancement of EGF receptor signaling