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DDIT3 — MAPK6
Text-mined interactions from Literome
Hattori et al., J Interferon Cytokine Res 2001
(Melanoma) :
Unexpectedly,
CHOP was constitutively phosphorylated, and IL-1 or p38
MAPK inhibitor, SB203580, did not
affect the phosphorylation level
Devries-Seimon et al., J Cell Biol 2005
(Atherosclerosis) :
Here we show that p38
MAPK signaling is
necessary for
CHOP induction and apoptosis
Ou et al., Eur J Pharmacol 2007
(Carcinoma, Renal Cell...) :
Selective inhibitors of ERK, p38
MAPK , and JNK
suppressed the induction of GRP78,
CHOP , and PPAR-beta, attenuated indomethacin induced cytotoxicity and reduced increased caspase activity
Yang et al., J Biol Chem 2007
(Diabetes Mellitus) :
Inhibition of p38
MAPK , but not of ERK1/2,
inhibited the expression of BiP and
CHOP and decreased H2S stimulated apoptosis, suggesting that p38 MAPK activation functions upstream of ER stress to initiate H2S induced apoptosis
Lawrence et al., Proc Natl Acad Sci U S A 2007
(MAP Kinase Signaling System) :
Differential
regulation of
CHOP-10/GADD153 gene expression by
MAPK signaling in pancreatic beta-cells
Shao et al., J Biol Chem 2010
:
Here, we show that nuclear factor kappaB (NF-kappaB) and
mitogen activated protein kinase ( MAPK ) signaling pathways
regulate the expression of CCAAT/enhancer binding protein homologous protein (
CHOP ), which mediates endoplasmic reticulum stress induced apoptosis
Park et al., Biochem Pharmacol 2011
:
However, these MG132 induced apoptotic events, with the exceptions of upregulation of Grp78/BiP and
CHOP/GADD153 and
activation of JNK and
p38MAPK , were abrogated by overexpression of Bcl-xL ... Pretreatment with the pan-caspase inhibitor z-VAD-fmk prevented MG132 induced apoptotic caspase cascade, but allowed upregulation of Grp78/BiP and
CHOP/GADD153 levels,
activation of JNK and
p38MAPK , d?m loss, and cleavage of procaspase-9 ( 47kDa ) to active form ( 35kDa )