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IRF6 — TP53

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Chen et al., J Leukoc Biol 2002 : This conclusion is supported by experiments using a chemical NO donor GSNO, in which RON activation directly blocked GSNO induced apoptotic death of Raw264.7 cells and inhibited LPS induced p53 accumulation
Munshi et al., J Immunol 2002 : LPS also augmented expression of the pro-apoptotic protein Bax and the tumor suppressor gene p53
Yan et al., Infect Immun 2004 : LPS activated the src-like kinases p59hck ( HCK ) and p58fgr ( FGR ) in both adult and newborn PMNs but increased the activation of p53/56lyn ( LYN ) only in adult cells
Meng et al., J Cell Physiol 2010 : To understand the mechanism by which LPS triggers the cell autophagy, we first investigated the effects of LPS on the expression of BIRC2 ( cIAP1 ), a well-known apoptosis inhibitor, and on the kinase activity of mammalian target of rapamycin (mTOR) and nuclear translocation of p53
Tsolmongyn et al., Cell Immunol 2013 : LPS inhibited VPA induced p53 activation and pifithrin-a as a p53 inhibitor as well as LPS prevented VPA induced apoptosis