◀ Back to CXCL13
CXCL13 — CXCR5
Pathways - manually collected, often from reviews:
-
KEGG Cytokine-cytokine receptor interaction:
CXCL13
→
CXCR5
(protein-protein, activation)
-
KEGG Chemokine signaling pathway:
CCL1/CCL11/CCL13/CCL14/CCL15/CCL16/CCL17/CCL18/CCL19/CCL2/CCL20/CCL21/CCL22/CCL23/CCL24/CCL25/CCL26/CCL27/CCL28/CCL3/CCL3L1/CCL3L3/CCL4/CCL4L1/CCL4L2/CCL5/CCL7/CCL8/CX3CL1/CXCL1/CXCL10/CXCL11/CXCL12/CXCL13/CXCL14/CXCL16/CXCL2/CXCL3/CXCL5/CXCL6/CXCL9/IL8/PF4/PF4V1/PPBP/XCL1/XCL2
→
CCR1/CCR10/CCR2/CCR3/CCR4/CCR5/CCR6/CCR7/CCR8/CCR9/CX3CR1/CXCR1/CXCR2/CXCR3/CXCR4/CXCR5/CXCR6/XCR1
(protein-protein, activation)
-
Reactome Reaction:
CXCL13
→
CXCR5
(direct_complex)
Legler et al., J Exp Med 1998*
-
Reactome Reaction:
CXCL13
→
CXCR5
(reaction)
Lambert et al., Science signaling 2008, Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, Takami et al., Brain Res Mol Brain Res 1994, Legler et al., J Exp Med 1998*
-
WikiPathways Chemokine signaling pathway:
CCL19/CCL27/CXCL3/CXCL10/XCL1/CXCL9/CCL21/CCL1/CCL11/CCL7/CCL17/CCL20/CCL22/CCL25/CCL27/CCL3/CCL4/CCL5/CCL15/CCL7/CCL15/CXCL3/CXCL5/CX3CL1/CXCL12/CCL19/CCL26/CXCL13/CXCL11/CCL24/PF4/CCL28/CXCL14/PPBP/CCL21/CXCL16
→
CXCR5/CCR6/CXCR2/CXCR3/CXCR4/CCR1/CCR9/CCR1/CCR3/CCR2/CCR4/CCR2/CCR7/CCR8/CCR10/CX3CR1/CXCR2/XCR1/CXCR6
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Dip Interaction:
CXCL13
—
CXCR5
(physical association, experimental interaction detection)
Legler et al., J Exp Med 1998*
-
IRef Hprd Interaction:
CXCL13
—
CXCR5
(in vitro)
Legler et al., J Exp Med 1998*, Gunn et al., Nature 1998*
-
IRef Hprd Interaction:
CXCL13
—
CXCR5
(in vivo)
Legler et al., J Exp Med 1998*, Gunn et al., Nature 1998*
-
IRef Ophid Interaction:
CXCL13
—
CXCR5
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Widney et al., J Interferon Cytokine Res 2005
(HIV Infections...) :
Elevated levels of
CXCL13 could cause impaired or altered trafficking of B cells during HIV infection and could
contribute to the previously reported loss of
CXCR5 , the receptor for CXCL13, from the surface of circulating B cells in HIV infection
Pandruvada et al., Int J Cancer 2010
(Carcinoma, Squamous Cell...) :
Interestingly,
CXCL13 treatment to OSCC cells
induced CXCR5 and MMP-9 expression suggesting an autocrine regulatory function in OSCC cells
El Haibi et al., Molecular cancer 2010
(Prostatic Neoplasms) :
We have previously shown that PCa tissue and cell lines express high levels of the chemokine receptor
CXCR5 , than compared to their normal counterparts, and interaction of CXCR5 with its specific ligand (
CXCL13 )
promoted PCa cell invasion, migration, and differential matrix metalloproteinase ( MMP ) expression