Gene interactions and pathways from curated databases and text-mining

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HSPG2 — SRC

Text-mined interactions from Literome

Etienne-Manneville et al., J Immunol 2000 (Calcium Signaling) : Our results suggest that PLC are responsible , via a calcium- and protein kinase C ( PKC ) -dependent pathway, for p60Src activation and tyrosine phosphorylation of the p60Src substrate, cortactin
Sato et al., Dev Growth Differ 2001 (MAP Kinase Signaling System) : Recently, it was found that Src family tyrosine kinase (SFK) dependent phospholipase C (PLC) activity is necessary for the calcium transience in fertilized Xenopus eggs
Amyere et al., Int J Med Microbiol 2002 : v-Src and K-Ras activate PI3K and PLC , as demonstrated by in situ production of the corresponding lipid products
Buitrago et al., Eur J Biochem 2002 : Inhibition of 1 alpha,25 ( OH ) ( 2 ) D ( 3 ) -induced c-Src activity by its specific inhibitor PP1 or muscle cell transfection with an antisense oligodeoxynucleotide directed against c-Src mRNA, prevented hormone stimulation of PLC gamma tyrosine phosphorylation
Sachdev et al., BMC cancer 2009 (Colonic Neoplasms...) : The Src induced phosphorylation of Eps8, PLC-gamma 1 and Shc ( poY239/poY240 ) were not affected by either FAK or adherence status
Kertész et al., Eur J Clin Invest 2012 (Bone Resorption...) : PLC?2 was phosphorylated in a Src-family dependent manner upon macrophage adhesion but not upon stimulation by M-CSF or RANKL
Khare et al., J Clin Invest 1997 : 1,25 dihydroxyvitamin D3 stimulates phospholipase C-gamma in rat colonocytes : role of c-Src in PLC-gamma activation ... Inhibition of 1,25 ( OH ) 2D3 induced Src activation by PP1, a specific Src family protein tyrosine kinase inhibitor, blocked the ability of this secosteroid to stimulate the translocation and tyrosine phosphorylation of PLC-gamma in the basolateral membrane (BLM)