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LOX — PTGS2

Text-mined interactions from Literome

Xu et al., Neoplasia (New York, N.Y.) 2003 (Esophageal Neoplasms) : The COX-2 inhibitor, NS398, induced 15-LOX-2 expression in esophageal cancer cells, which is associated with reduced cell viability
Hong et al., Carcinogenesis 2004 (Colonic Neoplasms) : The results suggest that curcumin affects arachidonic acid metabolism by blocking the phosphorylation of cPLA(2), decreasing the expression of COX-2 and inhibiting the catalytic activities of 5-LOX
Kurusu et al., Reproduction 2009 : Our results indicate the probable presence of multiple LOX isoforms and that specific inhibition of LOX at an early stage of hCG signaling led to reduced PTGS2 activity and thus defective ovulation
Petit et al., J Biomed Mater Res A 2010 (Osteoarthritis) : COL10A1 expression was also suppressed by the specific cyclooxygenase-1 ( COX-1 : SC-560 ) and 5-lipoxygenase ( 5-LOX : MK-866 ) inhibitors, but not by COX-2 ( COX-2 inhibitor 2 ) and 12-LOX ( baicalein ) inhibitors