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BMP2 — MMP2

Text-mined interactions from Literome

Nakashima et al., Frontiers in bioscience : a journal and virtual library 2006 : In these cultures, MMP-13 mRNA expression was induced by BMP-2 in Wnt3a over expressing C2C12 ( Wnt3a-C2C12 ) cells but not in either Wnt5a over expressing C2C12 ( Wnt5a-C2C12 ) cells or vehicle transfected C2C12 cells ... However, membrane type-1 matrix metalloproteinase ( MT1-MMP ) and MMP-2 mRNA expression was not affected by either Wnt3a or BMP-2
Kumagai et al., Anticancer Res 2006 (Carcinoma...) : Gel zymography for matrix metalloproteinases ( MMPs ) and urokinase-type plasminogen activator ( uPA ) detection revealed that BMP-2 down-regulated the activity of MMP-9, but not of MMP-2 or uPA ... BMP-2 also reduced the secretion of MMP-9 into the culture media, but did not affect the secretion of MMP-2 , Timp-1, Timp-2 or Timp-3
Tang et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2008 (Lung Neoplasms...) : To explore the effect of bone morphogenetic protein-2 (BMP-2 ) on the expression of membrane Type 1-matrix metalloproteinase ( MT1-MMP ) and the activation of matrix metalloproteinase-2 (MMP-2) in human A549 lung carcinoma cells ... BMP-2 dose-dependently activated MMP-2 in A549 cells ... BMP-2 might promote MT1-MMP expression and MMP-2 activation in lung carcinoma cells, which can lead to the increase of extracellular matrix followed by acceleration of tumor cell migration and invasion
Gordon et al., Carcinogenesis 2009 (Neoplasm Invasiveness...) : Further, Smad1 is required for BMP induced invasiveness and partially responsible for BMP mediated increases in MMP-2 activity
Hu et al., Molecular vision 2008 : We examined BMP-2 expression in human scleral fibroblasts ( HSF ) and assessed the effects of recombinant human BMP-2 ( rhBMP-2 ) on HSF proliferation, matrix metalloproteinase-2 (MMP-2) , and tissue inhibitor of metalloproteinase-2 ( TIMP-2 )
Fukui et al., Anat Rec (Hoboken) 2010 : The aim of this study is to investigate whether BMP-2 regulates the oral sulcus formation of mouse embryonic tongue by modifying the expression of TIMP and MMP
Liu et al., Frontiers in bioscience (Landmark edition) 2012 (MAP Kinase Signaling System...) : Our data show that stimulation of PANC-1 cells with BMP2 induced MMP-2 secretion and activation, associated with decreased E-cadherin expression, resulting in epithelial-to-mesenchymal transformation ( EMT ) and cell invasion
Sasaki et al., Atherosclerosis 2013 (Atherosclerosis...) : MMP-2 deficiency reduced BMP-2 and osteocalcin expression in aortae in Apoe ( -/- ) mice at 30 weeks and 45-60-weeks-old, respectively