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CD4 — TGFB1
Text-mined interactions from Literome
Piccirillo et al., J Exp Med 2002
:
The
role of
TGF-beta1 in
CD4 ( + ) CD25 ( + ) suppressor function remains unclear
Green et al., Proc Natl Acad Sci U S A 2003
(Diabetes Mellitus, Type 1) :
Here, we show by using a CD8+ T cell mediated model of type 1 diabetes that
transforming growth factor ( TGF ) -beta-TGF-beta receptor signals are
critical for
CD4+CD25+ Treg cell regulation of autoreactive islet-specific cytotoxic T lymphocytes
Kumar et al., Clin Exp Allergy 2004
(Asthma...) :
Production of epithelial cell derived TGF-beta 1 appeared to be regulated by IL-13, while both IL-13 and
CD4 ( + ) T cells
regulated accumulation of
TGF-beta 1
Gunnlaugsdottir et al., Int Immunol 2005
(Necrosis) :
Anti-CD28 induced co-stimulation and TCR avidity regulates the differential
effect of
TGF-beta1 on
CD4+ and CD8+ naïve human T-cells
Veltkamp et al., Gut 2005
(Colitis) :
CD4+CD25+ but not CD4+CD25- cell transfer into BM -- > Tgepsilon26 mice reduced the number of tumour necrosis factor alpha+ CD4+ cells and
increased the secretion of
transforming growth factor beta by MLN cells
Xu et al., Am J Physiol Lung Cell Mol Physiol 2006
(Disease Susceptibility...) :
Depletion of
CD4+ , but not CD8+, T cells in T-bet-/- mice
diminished BLM induced lung fibrosis and the expression of
transforming growth factor-beta1
Luo et al., Proc Natl Acad Sci U S A 2007
(Diabetes Mellitus, Type 1) :
Here we show that beta-cell peptide pulsed dendritic cells (DCs) from nonobese diabetic ( NOD ) mice can effectively induce
CD4 ( + ) CD25 ( + ) Foxp3 ( + ) T cells from naïve islet-specific CD4 ( + ) CD25 ( - ) T cells in the
presence of
TGF-beta1
Lan et al., Journal of molecular cell biology 2012
:
We report that polyclonal
CD4 ( + ) Foxp3 ( + ) Treg cells
induced ex vivo with
transforming growth factor beta ( TGFß ) ( iTreg ) suppress a lupus-like chronic graft-versus-host disease by preventing the expansion of immunogenic DCs and inducing protective DCs that generate additional recipient CD4 ( + ) Foxp3 ( + ) cells
Brisbin et al., Benef Microbes 2012
:
The results demonstrated that chicken
CD4+ and CD8+ T-cells express TLR21 and that the various isolates of lactobacilli differentially
induces the expression of interleukin 10, interferon-gamma and
transforming growth factor beta