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CD4 — NOTCH1
Text-mined interactions from Literome
Fowlkes et al., J Immunol 2002
:
A reassessment of the
effect of activated
Notch1 on
CD4 and CD8 T cell development ...
Notch1 is not
essential for
CD4 or CD8 T cell development ; however, there are suggestions that multiple Notch family members may act in a redundant fashion during thymic development ... In theory, expressing a constitutively activated form of Notch in CD4 ( + ) CD8 ( + ) thymocytes could provide clues about the normal
role of
Notch in developing
CD4 and CD8 T cells
Tacchini-Cottier et al., Eur J Immunol 2004
(Leishmaniasis) :
Taken together, these results indicate that
Notch1 is not critically
involved in
CD4 ( + ) T helper 1 differentiation and in resolution of lesions following infection with L. major
Alam et al., Proc Natl Acad Sci U S A 2010
(Hepatitis, Animal) :
Notch mediated stimulation of
CD4 ( + ) T cells increased the production of IL-22 even in the absence of STAT3
Hunt et al., Mol Cell Biol 2011
:
This defect was recapitulated in vitro as Mtg16 ( -/- ) Lineage ( - ) /Sca1 ( + ) /c-Kit ( + ) ( LSK ) cells of the bone marrow or DN1 cells of the thymus failed to produce
CD4 ( + ) /CD8 ( + ) cells in
response to a
Notch signal