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CD4 — IL13

Text-mined interactions from Literome

Richards et al., Eur J Immunol 2000 : Glucocorticoids are highly effective in the treatment of allergy and asthma and inhibit the synthesis of IL-4, IL-5 and IL-13 by disease promoting CD4 ( + ) Th2 cells
Smith et al., Allergy 2004 (Asthma) : CD4 ( + ) CD25 ( + ) T cells suppressed both proliferation and IL-13 production by CD4 ( + ) CD25 ( - ) T cells before and after therapy but peptide therapy was not associated with any change in suppressive activity of these cells
Pepe et al., Curr Pharm Des 2006 : This Th1 polarizing activity is mediated by interleukin-12 released by infected CDs in the presence of CD4 ( + ) cells
Wells et al., J Allergy Clin Immunol 2007 (Inflammation...) : Adoptive transfer of transgenic antigen-specific CD8, but not CD4 , cells resulted in increased IL-12 levels and reduced IL-13 and IL-5 levels in bronchoalveolar lavage fluid, coupled with substantially reduced airway eosinophilia after repeated allergen inhalation, a process mimicked by intranasal administration of IL-12 and inhibited by anti-IL-12 antibody
Ariga et al., Immunology 2007 : Using T-cell receptor ( TCR ) transgenic mice, we demonstrate that TCR stimulation of naive CD4 ( + ) T cells induces transient T-bet expression, interleukin (IL)-12 receptor beta2 up-regulation, and GATA-3 down-regulation, which leads to T helper ( Th ) 1 differentiation even when the cells are stimulated with peptide loaded I-A ( b ) -transfected Chinese hamster ovary cells in the absence of interferon-gamma (IFN-gamma) and IL-12
Leech et al., J Immunol 2007 (Asthma...) : Most convincingly, transfer of CD4 ( + ) CD25 ( + ) Foxp3 ( + ) T cells from Ag naive mice ( natural Tregs ) abolished AAI, decreased dMLN IL-5 and IL-13 secretion, increased dMLN IL-10 secretion, abolished IgE, and decreased IgG1 Abs. Blocking IL-10 receptor function in vivo did not block the anti-inflammatory function of transferred natural Tregs but did restore dMLN IL-5 and IL-13 secretion
Newcomb et al., J Allergy Clin Immunol 2011 : However, little is known about how IL-13 regulates human CD4 ( + ) T-cell lineages because IL-13 receptor (IL-13R) a1, a subunit of IL-13R, has not previously been reported to exist on human T cells
Reyes et al., Am J Transplant 2013 (Conjunctivitis, Allergic...) : Exogenous IL-4, but not IL-5 or IL-13 , prevented Treg suppression of CD4 ( + ) effector T cells isolated from naïve mice
Kinyanjui et al., J Immunol 2013 (Bronchial Hyperreactivity...) : IL-13 also increased numbers of IL-17 producing CD4 ( + ) and ?d T cells
Vandergeeten et al., Blood 2013 (HIV Infections) : When administered to HIV infected subjects receiving suppressive ART, interleukin-7 (IL-7) increases the number of CD4 ( + ) T cells by promoting their survival and proliferation
de Waal Malefyt et al., Int Immunol 1995 : Differential regulation of IL-13 and IL-4 production by human CD8+ and CD4+ Th0, Th1 and Th2 T cell clones and EBV transformed B cells
Suzuki et al., J Virol 1999 : Among them, interleukin-12 (IL-12) and IL-4 induce naive CD4 ( + ) T cells to become T-helper 1 ( Th1 ) or Th2 cells, respectively
Li et al., J Immunol 1998 (Hypersensitivity, Immediate...) : In contrast, the median CD4 dependent IL-13 response among atopics was markedly stronger than nonatopics in Ag-stimulated primary culture ( p = 0.0031 ) and exhibited a strong correlation with IL-5 ( r = 0.76, p = 0.0009 ), but not IL-4 ( r = 0.14, p > 0.05 ), responses