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RAC1 — SLC2A4
Text-mined interactions from Literome
Khayat et al., J Cell Sci 2000
:
Transient transfection of dominant inhibitory
Rac1 ( N17 ) into L6 myotubes prevented formation of dorsal actin structures and
blocked insulin induced
GLUT4myc translocation to the cell surface
Randhawa et al., J Biol Chem 2008
:
GLUT4 vesicle recruitment and fusion are differentially
regulated by
Rac , AS160, and Rab8A in muscle cells
Ueda et al., FASEB J 2010
:
We show that ectopic expression of constitutively activated
Rac1 , as well as intravenous administration of insulin,
caused translocation of
GLUT4 to the gastrocnemius muscle sarcolemma, as revealed by immunofluorescent staining of a transiently expressed exofacial epitope tagged GLUT4 reporter ... Collectively, we propose a critical
role of
Rac1 in insulin dependent
GLUT4 translocation to the skeletal muscle sarcolemma, which has heretofore been predicted solely by cell culture studies
Nozaki et al., Cell Signal 2012
:
The purpose of this study is to examine the involvement of RalA in
Rac1 regulation of the translocation of
GLUT4 to the plasma membrane in muscle cells ...
GLUT4 translocation
induced by constitutively activated mutation of Rac1 or more physiologically by upstream
Rac1 regulators, such as phosphoinositide 3 kinase and the guanine nucleotide exchange factor FLJ00068, was abrogated when the expression of RalA was downregulated by RNA interference ... Collectively, we propose a novel mechanism involving RalA for
Rac1 mediated
GLUT4 translocation in skeletal muscle cells
Chiu et al., J Biol Chem 2013
(Insulin Resistance) :
Interestingly, constitutively active
Rac-1 expression
results in a hormone independent increase in surface
GLUT4 ; however, the molecular mechanism and significance behind this effect remain unresolved